A facile synthesis of flavone derivatives used as potent anti-inflammatory agents.
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2011, Vol 3, Issue 0
Abstract
In the present study, a series of flavone derivatives [4a‐4h] were synthesized by condensation of acetophenone derivatives and aldehyde derivatives in ethanolic solution of potassium hydroxide followed by cyclization. Several flavones have been synthesized and their biological activity (Antiinflammatory) investigated using the model of carrageenan induced rat paw edema. The results showed that compound (4)f shows the higher antiinflammatory activity. The synthesized compounds have been characterized by using Mass, IR and 1H NMR Spectral data together with elemental analysis.
Authors and Affiliations
DHARMA THEJA N , TULASI CHOUDARY P , madhusudhanareddy I, GUPTA AVSSS , KOTI REDDY U
Keywords
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