A Fetal Study of Craniorachischisis, With Emphasis on Prenatal Diagnosis and Prevention
Journal Title: Journal of Medical Science And clinical Research - Year 2016, Vol 4, Issue 4
Abstract
Introduction: Central nervous system (CNS) malformations constitute a sizeable percentage of the total incidence of the congenital malformations second only to cardiac malformations. Failure of fusion of cephalic part of neural tube is known as Exencephaly and caudal part of neural tube is Spina bifida. Aim: This study was aimed at providing a comprehensive knowledge of Craniorachischis is which is characterized by anencephaly accompanied by open spina bifida. It was also associated with congenital fissure in the skull and vertebral column. This is the severe form of NTDs and recent evidences proves folic acid reduces the occurrence of NTDs 50-70% when taken periconceptionally. Therefore emphasis was based on prenatal diagnosis and prevention. Methods and Results: The present study includes 1000 live births with 100 stillborn foetuses and abortuses to elucidate Craniorachischisis. The two unclaimed foetuses, one Craniorachischisis totalis and other being Craniorachischisis with omphalocele we resent from the department of Obstetrics and Gynecology. The detail Family and Obstetric history was not available. Discussion: Neural tube defect (NTDs) is an embryonic induction disorder which results from failure of formation of both mesoderm and neuroectoderm. The reduction of 50-70% of NTDs following periconceptional folic acid administration initiated series of clinical studies by number of authors. Conclusion: In conclusion most NTDs are sporadic and both genetic and non-genetic environmental factors are involved in its etiology
Authors and Affiliations
Dr Gayathri. P
Keywords
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