A FOCUS ON FAILURE OF DRUG THERAPY FOR TARGETING CANCER STEM CELL: A REVIEW
Journal Title: European Journal of Pharmaceutical and Medical Research - Year 2018, Vol 5, Issue 1
Abstract
Medical oncology and innovation in pharmaceutical industry, targeted therapy provides physicians and patients with more options to improve clinical outcomes as evidenced by improvement in overall survival (OS), progression-free survival (PFS), and response rate (RR), among other end points. Effective anti-cancer treatments have been able to eliminate macroscopic tumors both at primary sites and at common distal sites. There has been a consensus that, to improve the results of targeted therapy, challenging drug resistance problems needs to be solved through better understanding the mechanisms. Nevertheless, even if they showed an impressive response to treatment initially, the majority of cancer patients relapsed because small cohorts of tumor cells can survive in cryptic anatomic loci and exhibit up to 90% resistance to one or more therapeutic agents for months or year(s). As such, drug resistance has been a major hurdle for classic anti-cancer medicines, and it still is a great challenge facing the emerged array of targeted therapies. In this article, we provide a comprehensive overview regarding cancer stem cell targeted therapy resistance.This review aims to focus on Concept of growth of cancer stem cell and describe the Failure to avoid drug resistance when targeting cancer cell as well as modifications inducing cancer cell resistance to chemotherapy.
Authors and Affiliations
Kharade Sudha
Keywords
Related Articles
- EP ID EP635084
- DOI -
- Views 154
- Downloads 0
LIGATIONAL AND SPECTROSCOPIC ON SOME SULFAMETHOXAZOLE METAL COMPLEXES AS ANTIMICROBIAL AGENTS
Metal complexes have been applied as medicinal agents in the treatment of differenthuman infections and diseases. So, the aim of this study is focused on studying theligational, spectroscopic and evaluating antimicrobial...
EX-VIVO PERMEABILITY STUDIES OF DIHYDROARTEMISININ-PIPERAQUINE ANTIMALARIAL IN THE PRESENCE OF FOOD COMPONENTS
The work was aimed at assessing the interactions between dihydroartemisinin-piperaquine (DP) with food components. Food components [i.e., albumin (ALB), starch (STC) and sunflower oil (SFO)] were co-loaded simultaneously...
STRUCTURAL CHARACTERISTICS, ANTITUMOR AND ANTI-INFLAMMATORY PROPERTIES OF POLYSACCHARIDES ISOLATED FROM THE RED ALGAE TRICLEACARPA FRAGILIS GROWING ON THE LEBANESE COAST.
Objective: The purpose of this study was to extract, to determine the functional groups and to examine the anti-proliferative and the anti-inflammatory effect of the polysaccharides sulfated galactan and carrageenan extr...
A COMPARATIVE STUDY OF THE IN VITRO ACTIVITIES OF TWO ANTIFUNGAL AGENTS ON CANDIDA ALBICANS
Candida albicans is the principal cause of candidiasis in women. A comparative study of the in vitro activities of two antifungal agents was carried out using clotrimazole and nystatin. Two hundred and fifteen (215) Cand...
COMPARATIVE STUDY OF ASYMPTOMATIC BACTERIURIA AMONG HIV SERO-POSITIVE AND HEALTHY INDIVIDUALS IN PORT-HARCOURT, NIGERIA
The study aimed to analyse the incidence of Asymptomatic bacteriuria in Human immunodeficiency virus (HIV) sero-positive and sero-negative individuals and the spectrum of bacterial uropathogens among these 2 populations...