A game of survival: herpesvirus strategies of autophagy manipulation
Journal Title: Advances in Hygiene and Experimental Medicine - Year 2014, Vol 68, Issue
Abstract
Viruses are a very “clever” group of pathogens and well known for disrupting multiple processes in host cells. One of them is autophagy, a conserved mechanism that relies on degradation of intracellular structures in lysosomes. Autophagy can be triggered in response to viral infections and its aim is to digest viral particles, thereby limiting virus replication and spread. Induction of autophagy during viral infections is mediated by different regulatory pathways, but the biggest participation belongs to PKR and eIF2alpha. In this review we focused on the herpesvirus interactions with autophagic machinery. The Herpesviridae family presents various strategies to manipulate autophagy induction or suppression of that process may depend on cell type and stage of infection. Research carried out in the past 10 years has demonstrated the impact of herpesviruses on autophagy not only during productive infections, but in latency infections also.
Authors and Affiliations
Dariusz Miszczak, Joanna Cymerys
Keywords
Related Articles
- EP ID EP67540
- DOI -
- Views 149
- Downloads 0
Molekularne markery karcynogenezy w diagnostyce raka szyjki macicy
Rak szyjki macicy jest najczęstszym nowotworem złośliwym narządu rodnego, zajmuje drugie miejsce pod względem częstości występowania u kobiet, zaraz po raku piersi. Cechuje się również wysoką umieralnością, dlatego też p...
Immunology of the eye
The eye is an organ of sight characterized by unusual immunological properties, resulting from its anatomical structure and physiology, as well as the presence of specific elements that, through the mechanisms of innate...
Metaloproteinazy w raku krtani
Rak krtani to najczęstszy nowotwór złośliwy głowy i szyi. Mimo postępu w medycynie rokowanie u chorych na ten nowotwór w dalszym ciągu jest niezadowalające. W ostatnich latach duże zainteresowanie wzbudzają, odgrywające...
Plants as an alternative source of therapeutic proteins
In recent years, there has been an increased interest of researchers in developing efficient plant heterologous expression systems of proteins for a wide range of applications. It represents an alternative to the traditi...
Nicotine-induced resistance of non-small cell lung cancer to treatment – possible mechanisms
Cigarette smoking is the leading risk factor of lung cancer. Data from several clinical studies suggest that continuation of smoking during therapy of tobacco-related cancers is associated with lower response rates to ch...