A GLOBAL COMPARISON AND ANALYSIS OF NEURAMINIDASE H1N1 STRAIN OF INFLUENZA A
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2015, Vol 7, Issue 4
Abstract
Objective: To evaluate the variation of neuraminidase (NA) protein from various H1N1 strain for drug designing.Methods: In this study we have used 12 sequences of NA protein from various countries, retrieved from UniprotKB database. We have performed structural analysis, antigenic and glycosylation site prediction between NA proteins of influenza A strains.Results: Antigenic variants in sequence of NA H1N1 strain from Italy were found to be unique and were not present in any other NA H1N1. Strains from Italy and Thailand were found to be distantly related while others are closely related. We observed the maximum similarity from position 84 to 448 using disorder prediction analysis of different strains. Sequences from 1 to 83 and 449 to 469 showed the maximum dissimilarity among the NA Proteins.Conclusion: This study focuses on the regions of sequence similarity and dissimilarity of NA in H1N1 strains from different countries. The results in this paper are based on currently available sequences for NA of H1N1 strains and bioinformatic tools. Our study will help in understanding of the regions of high variability due to mutations and conserved domains that can be potential targets for drug development.
Authors and Affiliations
Prashant Saxena, Shashank Shrishrima, Inamul Hasan Madar
EXTRACTION OF FLAVONOIDS FROM BUCHANANIA LANZAN SPRENG. SEEDS BY SUPERCRITICAL FLUID EXTRACTION AND DETERMINATION OF THEIR ANTIOXIDANT ACTIVITY
Objective: The purpose of the study is to optimize supercritical fluid extraction (SFE) conditions for the flavonoids from the seeds of Buchanania lanzan Spreng. followed by quantitative determination of the antioxidant...
BRIEF REVIEW ON THE MEDICINAL USES AND ANTIMICROBIAL ACTIVITY OF DIFFERENT PARTS OF SCHINUS TEREBINTHIFOLIUS RADDI
Populations all over the world make use of medicinal plants to treat health problems. Plants are pertaining to the Anacardiaceae family which largely occur throughout Brazil, such as the Schinus terenbithifolius Raddi sp...
ENHANCEMENT OF ORAL BIOAVAILABILITY OF REPAGLINIDE BY SELF-NANOEMULSIFYING DRUG DELIVERY SYSTEM
Repaglinide is considered the drug of choice for diabetic patients with impaired kidney function as it is excreted mainly in the bile. Unfortunately, it possesses low oral bioavailability of approximately 56 %. Therefore...
VALIDATION OF ACCUMULATION OF CAMPTOTHECIN CONTENT, AN ANTI-CANCER ALKALOID IN NOTHAPODYTES NIMMONIANA GRAHAM. IN PHENOTYPIC VARIANTS: METHOD FOR IDENTIFYING HIGH-YIELDING SOURCES OF ALKALOID
Objective: The study was aimed to find the CPT accumulation, in particular organ, via variable extraction method and in vitro propagation method both qualitatively and quantitatively.Methods: In the present study, the se...
ECONOMIC MAXIMIZATION OF ALFALFA ANTIMICROBIAL EFFICACY USING STRESSFUL FACTORS
Objective: The present study addresses the effect of water deficit stress on the antimicrobial capacity of alfalfa (Medicago sativa) plants. Methods: Methanolic extracts of alfalfa plants grown in different soil types, v...