A Hospital Based Observational Study To Find The Correlation of The Demographic Profile And Clinical Features With The Outcome In Patients With Acute Encephalitis Syndrome And To Study The Disease Pattern In The Population
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2017, Vol 16, Issue 12
Abstract
Introduction:Acute Encephalitic syndrome(AES) is a major public health problem worldwide.Japanese encephalitis(JE) is one of the leading causes of acute encephalopathy affecting children. Aims&Objectives:1/To find out the correlation of demographic profile and clinical features with the outcome of AES patients(recovery with or without sequelae or death) 2/To study the outcome and common etiological agents of AES Materials&Methods:Patients admitted in the Paediatrics Department of AMCH with diagnosis of AES in 1 year were enrolled at admission. Informed consent was taken from the guardians.Ethical committee clearance was taken. Demographic profile, clinical features& outcome was observed in these patients.Analysis was done by SPSS.16 Result:Total 201 cases were admitted during the study period(Male:124,female:77, children less than 1 year:21, 1 to <5 years:68 ,5- 7 years:112).No significant correlation of age(p0.23), sex(p0.71),time interval between disease onset to hospital admission(p0.398),distance of home to nearby health facility(0.917) with outcome was found while there was significant correlation of ethnic group(p0.002),nutritional status(p0.000),socioeconomic status(p0.001),temperature(p0.000),GCS(p0.000)&episodes of seizure(p0.000)with outcome in AES patients. AES cases occurred more in Tea tribe community& adverse outcome(fatality and death) is also more in the population(n=54,57%).Significant correlation of JE with JE vaccination(p0.000) and outcome(p0.000) was found.Common neurological sequelae were aphasia(97%), behavioural disorders(57%),motor deficit (49%),cranial nerve palsy(22%), abnormal movements like facial tics(11%).Most common etiological agent was Japanese encephalitis(57%,n=114). Conclusion:This is the first study done in this population trying to look at the demographic& clinical parameters which can be used to predict the outcome in AES patients without using any laboratory parameter.Most of the factors found associated with adverse outcome are preventable to a greater excent.
Authors and Affiliations
Dr. Murchana Khound MD, Dr. Pritikar Dowerah MD
Keywords
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- EP ID EP250815
- DOI 10.9790/0853-1612072226
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