A hospital-based study of hepatic dysfunction in children with dengue fever

Journal Title: Asian Pacific Journal of Tropical Disease - Year 2015, Vol 5, Issue 12

Abstract

Objective: To study the hepatic dysfunction in children with dengue infection and find out its correlation with the severity of dengue fever. Methods: Seventy-two cases of dengue fever as per the World Health Organization aged from 2 months to 18 years of age guidelines serologically confirmed by dengue NS1 antigen detection or dengue IgM capture ELISA were studied for their hepatic dysfunction after excluding malaria, enteric fever, hepatitis A and hepatitis B. The duration of the study was from April 2013 to March 2014. Results: These 72 cases were grouped into severe dengue, dengue fever with warning sign and dengue fever without warning sign as per the World Health Organization guidelines. The spectrums of hepatic manifestations included hepatomegaly (66%), hepatic tenderness (44%), jaundice (9.72%), raised levels of aspartate transaminase (86%), alanine transaminase (90%), alkaline phosphatase (39%), prolonged prothrombin time (11%) and reduced levels of serum albumin (66%). Conclusions: Tender hepatomegaly and elevated liver enzymes were seen more frequently in severe dengue. There was significant derangement between liver function and tender hepatomegaly. Altered liver function may be evident even in the absence of hepatomegaly.

Authors and Affiliations

Keywords

Related Articles

Fabrication and Evaluation of Tinidazole Microbeads for Colon Targeting

Objective: The purpose of present investigation was to develop and evaluate multiparticulate system exploiting pH-sensitive property and specific biodegradability of calcium alginate microbeads, for colon- targeted deliv...

Additional records of vector mosquito diversity collected from Al Khor district of North-eastern Qatar

Objective: To survey mosquito diversity in the north-eastern area, which includes the most important gas industrial city in Qatar, and to investigate the potential mosquitoes for transmitting diseases. Methods: A study w...

First detection on prevalence of Anaplasma marginale in sheep and goat in Karak District, Pakistan

Objective: To evaluate prevalence of Anaplasma marginale (A. marginale) and associated risk factors in sheep and goat. Methods: A total of 500 blood samples (250 from sheep and 250 from goat) were collected from three di...

Development and validation of a meat juice ELISA for the diagnosis of Fasciola hepatica in cattle in Cuba

Objective: To establish and validate a home-made ELISA for determination of antibodies against excretory-secretory proteins of Fasciola hepatica in bovine meat juice samples. Methods: The validity criteria of the assay w...

Evaluation of cases with Fasciola hepatica infection: experience in 6 children

Objective: To evaluate 6 pediatric cases diagnosed as fascioliasis. Methods: Patients diagnosed as fascioliasis are retrospectively interpreted. Results: Herein 6 pediatric cases having a mean age of (12.7±3.1) years wit...

Download PDF file
  • EP ID EP228444
  • DOI 10.1016/S2222-1808(15)60965-3
  • Views 95
  • Downloads 0

How To Cite

(2015). A hospital-based study of hepatic dysfunction in children with dengue fever. Asian Pacific Journal of Tropical Disease, 5(12), 964-967. https://europub.co.uk/articles/-A-228444