A mathematical approach in the management of hydrocephalus from tuberculous meningitis
Journal Title: National Journal of Physiology, Pharmacy and Pharmacology - Year 2017, Vol 7, Issue 11
Abstract
Background: The unavailability of standardized treatment algorithms to properly select tuberculous meningitis (TBM) patients for surgery delays optimal management. Aim and Objective: This study developed a mathematical model as an objective guide in deciding whether to perform surgical intervention or not among patients with hydrocephalus from TBM. Materials and Methods: Using 13 different clinical and cerebrospinal fluid parameters, a saturated logistic regression model was developed and tried retrospectively on 37 previously managed cases of hydrocephalus from TBM. Results: The model is statistically significant (P = 0.0170) with 93.2% concordance index in predicting physician’s decision on admission whether the patient will undergo surgical intervention or not. Patients are recommended for surgical intervention if g-score >0.04 with 90.48% sensitivity. Conclusion: With its significant P-value and high concordance index, the model is a good representative of the actual decision making of physicians in the management of hydrocephalus from TBM.
Authors and Affiliations
Gerard Raimon M Saranza, Derick Erl P Sumalapao, Julette Marie F Batara, Carlene P Arceo
Keywords
Related Articles
- EP ID EP292100
- DOI 10.5455/njppp.2017.7.0517402072017
- Views 50
- Downloads 0
Perception of stress among yoga trained individuals
Background: Yoga, originated thousands of years ago in India, is now well recognized as a form of mind-body medicine. Regular practice of yoga in the form of postures and breathing techniques stabilizes the autonomic ner...
Impact of chronic smoking on lipid peroxidation and electrocardiogram in ischemic heart disease patients
Background: Cigarette smoking is one of the prime contributing factors for atherosclerosis. Chronic cigarette smoking causes disturbances in the electrophysiology of heart and may lead to ventricular arrhythmias. Further...
Effect of gum arabic and Nigella sativa on T-helper1 and T-helper2 immune response in Wistar rats infected with methicillin-resistant Staphylococcus aureus
Background: The herbal medications are widely used in folk medicine for treatment of variable diseases and infection. Staphylococcus aureus (Sa) is a Gram-positive bacteria that cause severe organ affection, especially i...
Waist-related anthropometric measures: Simple and useful predictors of coronary heart disease in women
Background: Waist circumference (WC) (abdominal girth), a measure of both subcutaneous and visceral fats, is easily measured and also correlated with body frame size. Waist circumference (WC) a...
Antifungal properties of soleshine - An in vitro study
Background: Soleshine is a polyherbal formulation meant to be used to heal cracks on heels, protecting sole from chaffs, marketed by Rumi Herbal Pvt Ltd., Chennai. The active ingriedients are Azadirachta indica, Lawsonia...