A Meta-analysis of blood miRNA as a diagnostic biomarker for endometriosis
Journal Title: Biomedical Transformation - Year 2022, Vol 3, Issue 4
Abstract
Objective The value of blood miRNA for the diagnosis of endometriosis was evaluated by Metaanalysis, for which it was identified as a non-invasive diagnostic biomarker to distinguish endometriosis. Methods English and Chinese language databases were searched for relevant literature on blood miRNAs for the diagnosis of endometriosis reported up until September 2022. The appropriate data was derived from the literature and analyzed and assessed using Stata14.0 and RevMan5.4. Results A total of 24 relevant papers were included. As a diagnostic tool for endometriosis, blood miRNA has an overall sensitivity of 0.86, specificity of 0.84, positive likelihood ratio of 5.3, negative likelihood ratio of 0.17, diagnostic odds ratio (DOR) of 31, and area under the curve (AUC) of 0.91. The research featured meta-regression and subgroup analysis, and the upregulation of expression by miRNA in blood serum, Asian and African populations had a higher accuracy value for diagnosing endometriosis. Conclusion Blood miRNAs can thus be used as diagnostic biomarkers for endometriosis, with the miRNAs upregulation in serum expression having a higher diagnostic value for diagnosing endometriosis in Asianand African populations.
Authors and Affiliations
Liu Chang, Li Wenqian, Wei Xinyan, Shan Hongying
Keywords
Related Articles
- EP ID EP766859
- DOI 10.12287/j.issn.2096-8965.20220409
- Views 13
- Downloads 0
T lymphocytes development and aging
T lymphocytes, as a vital component of the adaptive immune system, play a crucial role in maintaining immune health. A thorough investigation of their maturation and aging processes is essential for achieving a comprehen...
Cholesterol metabolism and immune response
Cholesterol and its various metabolites are essential components of cell and organelle membranes, playing crucial roles in regulating membrane mobility, permeability, lipid raft formation, and signal transduction. Recent...
Current status and future prospects of artificial intelligence in traditional Chinese medicine
Traditional Chinese Medicine (TCM) has not been widely accepted in the world for the lack of objective data and complete theoretical system. In addition, the ambiguous of language, the difficulty in understanding theoret...
DNA methylation and histone modificationsin mammalian oocytes
The unique patterns of epigenetic modifications appear in mammalian oocyte development. Establishment of these modifications, including DNA methylation and histone modifications, is a complicated but highly ordered proce...
Translational medicine and traditional Chinese medicine research practice
More and more scholars have paid attention to traditional Chinese medicine since the concept of translational medicine was introduced into this field. Most scholars believe that it is of great benefit to the inheritance...