A meta-analysis of integration of Traditional and Western Medicine treatment versus Western treatment in patients with lupus nephritis
Journal Title: Journal of Medical Biomedical and Applied Sciences - Year 2017, Vol 5, Issue 12
Abstract
Objective:To systematically evaluate the clinical effect of integrated traditional Chinese medicine and Western Medicine (TCM-WM) and to investigate effective therapy of traditional Chinese medicine (TCM) for lupus nephritis(LN). Methods A meta-analysis was performed of all the literatures germane to estimate the patients treated with TCM-WM and western medicine(WM ) alone from published randomized controlled trials (RCTs) from 1990 to February 2013. Relative risk (RR) and 95% confidence intervals (CIs) were calculated and the meta-analysis was conducted with Revman5.2 software. GRADE Profile3.6 was used to evaluate the quality of the evidence. Results 12 RCTs were included. The complete remission rate(RR =1.58, 95%CI 1.4-1.78, P<0.00001) and the total remission rate(RR =1.18, 95%CI 1.13-1.24, P<0.00001) of TCM-WM were higher than that of WM .The relapse rate(RR =0.32, 95%CI 0.22-0.44, P<0.00001), incidence of adverse reactions(RR =0.47, 95%CI 0.41-0.55, P<0.00001)and mortality rate(RR =0.38, 95%CI 0.23-0.63, P=0.00002) of TCM-WM were much lower than WM. Conclusion Our results indicate that TCM-WM therapy may be superior to therapy with WM alone. However, due to the lower quality of the included studies, high quality of multicenter, large sample, randomized and double-blind controlled trials are needed to validate the result.
Authors and Affiliations
Dr Ronghua Zhang Fangxiang Mu, Yi Jang, Feige Ao, Xiaochuan Hu, Yang Meng, Dejun Jiang and Qinghua Zou
Keywords
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- EP ID EP313673
- DOI 10.15520/jmbas.v5i12.81
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