A MODEL OF TYPE II DIABETES IN RAT USING LOW FRUCTOSE DIET AND ALLOXAN
Journal Title: INTERNATIONAL JOURNAL OF PURE MEDICAL RESEARCH - Year 2018, Vol 3, Issue 1
Abstract
This study aimed at developing a type II diabetic animal model with low mortality, suitable for chronic studies using low fructose diet and a single injection of alloxan. Thirty male Wister rats weighing between 150g-200g were equally divided into ve groups. Group 1 (control) drank distilled water while groups 2 to 5 rats drank 20%w/v solution of fructose freely for 7days. Thereafter, groups 2, 3 and 4 rats received 20mg/kg-i.v, 40mg/kg-i.v and 150mg/kg-i.p alloxan respectively. Fasting Blood Glucose (FBG) was measured after fructose administration then 24hours, 6 weeks and 12 weeks after alloxan injection. Groups 2, 3 and 4 showed signicant increase in FBG (124mg/dl, P<0.05; 286mg/dl, p<0.01; 419mg/dl, p<0.001) compared with control (60mg/dl). These ndings showed that low fructose diet with a single injection of alloxan induces a diabetic condition of less severity, depending on the dose and/or route of administration of alloxan.
Authors and Affiliations
Fabiyi-Edebor T. D
Keywords
Related Articles
- EP ID EP598155
- DOI -
- Views 48
- Downloads 0
INTRACRANIAL CHRONIC EPIDURAL HEMATOMAS: TECHNICAL NOTE
Intracranial chronic epidural hematomas can be rarely found in patients victims of head trauma. The diagnosis is usually delayed because of the absence of neurologic focus signs. Re-bleeding is possibly the underlying me...
EFFECT OF MOBILE PHONE RADIATION ON ANTENATAL CARDIOTOCOGRAPHY AT 40 WEEKS AND MATERNAL AND NEONATAL OUTCOME
Objective: To study the effect of mobile phones on fetal cardiotocographic parameters. Material and Methods: One hundred and forty one low risk antenatal women at forty weeks of gestation were studied for the cardiotocog...
MULTIPLE ENDOCRINOPATHIES IN A YOUNG FEMALE – A CASE REPORT
Autoimmune polyendocrine/ polyglandular (APS) syndromes are constellations of multiple endocrine gland insufficiencies, of whom there are 3 types, and amongst which APS type II is the most common. APS type III is dened...
ROLE OF SCORING SYSTEMS AS A PROGNOSTIC FACTOR IN PATIENTS ADMITTED IN ICU WITH COPD AND RESPIRATORY FAILURE
Background and objectives:-. Chronic Obstructive Pulmonary Disease (COPD) represents an important public health challenge and is a major cause of chronic morbidity and mortality throughout the world .COPD is currently th...
FANTASTIC FRUITY PEBBLES: THE CANCERPROTECTIVE ROLE OF ARTIFICIAL COLORING IN BREAKFAST CEREALS
The purpose of this study is to examine the role that articial coloring has in breakfast cereals. In breakfast cereals, we examine articial coloring. Rigorous statistical analysis was performed. We nd that articial c...