A Modeling and Simulation Framework for Adverse Events in Erlotinib-Treated Non-Small-Cell Lung Cancer Patients

Journal Title: The AAPS Journal - Year 2015, Vol 17, Issue 6

Abstract

The online version of this article (doi:10.1208/s12248-015-9815-8) contains supplementary material, which is available to authorized users.

Authors and Affiliations

Ahmed Abbas Suleiman, Sebastian Frechen, Matthias Scheffler, Thomas Zander, Lucia Nogova, Martin Kocher, Ulrich Jaehde, Jürgen Wolf, Uwe Fuhr

Keywords

Related Articles

Ophthalmic drug design based on the metabolic activity of the eye: Soft drugs and chemical delivery systems

Despite its apparent easy accessibility, the eye is, in fact, well protected against the absorption of foreign materials, including therapeutic agents, by the eyelids, by the tearflow, and by the permeability barriers im...

Critical Factors Influencing the In Vivo Performance of Long-acting Lipophilic Solutions—Impact on In Vitro Release Method Design

Parenteral long-acting lipophilic solutions have been used for decades and might in the future be used in the design of depots with tailored delivery characteristics. The present review highlights major factors influenci...

DNA/polyethylenimine transfection particles: Influence of ligands, polymer size, and PEGylation on internalization and gene expression

Receptor-binding ligands have been incorporated into DNA/polyethylenimine (PEI) complexes to enhance cell binding and cellular internalization. This study characterizes receptor-mediated uptake of DNA/PEI complexes on a...

Download PDF file
  • EP ID EP681028
  • DOI  10.1208/s12248-015-9815-8
  • Views 43
  • Downloads 0

How To Cite

Ahmed Abbas Suleiman, Sebastian Frechen, Matthias Scheffler, Thomas Zander, Lucia Nogova, Martin Kocher, Ulrich Jaehde, Jürgen Wolf, Uwe Fuhr (2015). A Modeling and Simulation Framework for Adverse Events in Erlotinib-Treated Non-Small-Cell Lung Cancer Patients. The AAPS Journal, 17(6), -. https://europub.co.uk/articles/-A-681028