A modern approach to interleukin-6
Journal Title: Moldovan Medical Journal - Year 2018, Vol 61, Issue 3
Abstract
Background: Interleukin-6 is a multifunctional cytokine with well-defined pro- and anti-inflammatory properties. Binding to the receptor complex composed of specific interleukin-6-receptor (IL-6R) and transmembrane glycoprotein gp130, it stimulates various signalling cascades. Intracellular signal transduction involves both STAT-dependent, and STAT-independent mechanisms. IL-6R exists in the soluble and the membrane-bound forms, thus were described the classical signalling and the trans-signalling pathways. The pro-inflammatory response occurs via trans-signalling, while the antiinflammatory effects are mediated by classical signalling pathway. IL-6 is produced by cardiovascular components. The high levels of IL-6 are identified in the inflammatory diseases. Conclusions: IL-6 expresses the well-defined pro- and anti-inflammatory properties. The experimental studies have revealed classic signalling pathway with regenerative and anti-inflammatory effects (via the membrane-bound IL-6R), and trans-signalling responsible for the pro-inflammatory response (via the soluble form sIL-6R). The intracellular signal transduction involves the activation of STATs, MAPK, and PI3K cascades. It has been proved that in the cardiovascular pathologies the serum levels of IL-6 correlate with the disease severity and the degree of myocardial damage, being the indicator of heart disease and a predictive factor of adverse outcomes.
Authors and Affiliations
Tatiana Timercan
Keywords
Related Articles
- EP ID EP480545
- DOI 10.5281/zenodo.1299041
- Views 156
- Downloads 0
About causes of early-stage asymptomatic prostate cancer
Background: The neurotransmitters (epinephrine and norepinephrine) of the sympathetic nervous system that perform numerous cellular and tissue functions contribute to tumor growth during the early stages of development....
Medical-economic reasonings on the reform in the field of state surveillance of public health
Background: The functional organization of the service, institution or organization requires adjustment to challenges of the social, economic, and professional environment that intervene development stages of society. Th...
Clinical presentation, risk factors and outcomes of tuberculosis in military recruits
Background: Tuberculosis represents the major threat for the health protection in the military forces. The aim of this retrospective and descriptive study was the evaluation of risk factors, clinical presentation and tre...
Monoinvasion with toxocara canis in children
Background: Toxocariasis is a clinical notion that reflects human involvement with the Toxocara larvae in the second stage of development. Its typical syndromes are Larvae Migrans Visceralis, ocular toxocarosis , neurolo...
Pharmacists’ role in managing food supplements
Background: Every year, the value of the world market of Food Supplements (FS) increases considerably, especially following the accepting the role of nutrition in maintaining health. The share of official importers of me...