A Natural Formulation Increases Brain Resistance to Oxidative Stress
Journal Title: European Journal of Medicinal Plants - Year 2014, Vol 4, Issue 2
Abstract
Aims: Oxidative stress is an imbalance in the pro-oxidant/antioxidant homeostasis, characterized by excess accumulation of reactive oxygen/nitrogen species (ROS/RNS) and free radicals that can be toxic for cells by initiating disruptive peroxidation reactions on cellular substrates such as proteins, lipids, and nucleic acids. Neurons have a high content of unsaturated fatty acids which are easily peroxidable by the elevated levels of ROS and RNS produced by brain oxygen metabolism, yielding isoprostanes among which 8-iso-PGF2α derived from arachidonic acid represents a stable marker of lipoperoxidation, in vivo. Numerous findings pointed to the protective role of natural products against oxidative stress in the brain. Methodology: In the present work we evaluated the effects of a natural formula containing bacopa extract, vitamin E, astaxanthin and phosphatidylserine on lipoperoxidation in rat brain cortex, both in vivo and in vitro. Results: The results demonstrate that the natural formula could reduce basal and hydrogen peroxide- and amyloid β peptide-induced oxidative stress, as evidenced by the reduction of 8-iso-PFG2α and ROS/RNS production in the rat brain. Conclusion: Results could account for a rational use of herbal products in the treatment of conditions characterized by increased burden of oxidative stress and defective antioxidant mechanisms, such as aging and neurodegenerative disorders.
Authors and Affiliations
Luigi Menghini, Claudio Ferrante, Lidia Leporini, Giorgio Pintore, Annalisa Chiavaroli, Rugia Shohreh, Lucia Recinella, Giustino Orlando, Michele Vacca
Keywords
Related Articles
- EP ID EP350035
- DOI 10.9734/EJMP/2014/7150
- Views 95
- Downloads 0
Renal Protective Properties of Aqueous Extract of Bryophyllum pinnatum (Lam.) Oken Leaf against Petrol Vapour – Induced Toxicity on Male Albino Rats
The aim of this study was to investigate the renal protective properties of aqueous leaf extract of Bryophyllum pinnatum from Nigeria against petrol vapour – induced toxicity on the kidney of male albino rats. Fifty appa...
In vitro Anti-inflammatory Evaluation of African Nutmeg (Monodora myristica) Seeds
Aim: To determine the anti-inflammatory potential of flavonoid rich fraction of Monodora myristica seeds. Study Design: In vitro evaluation of anti-inflammatory assays: Membrane stability, Inhibition of denaturation of a...
Carica papaya Latex Accelerates Wound Healing in Diabetic Wistar Rats
Aim: The wound healing ability of Carica papaya latex in excisional wound of alloxan induced diabetic wistar rats was investigated. Methodology: The excisional wounds of 24 diabetic rats in four equal groups were dressed...
Assessement of Aqueous Plant Extract for the Control of Kola Weevils (Balanogastris kolae & Sophrorhinus spp) (Coleoptera: Curculionidae) in Stored Cola nitida
Kola nuts do not undergo any other additional form of post harvest processing before storage and consumption, hence there is an urgent need to develop new post harvest storage pest control strategies that are safe, of lo...
Microbiological Contamination and Anti-bacterial Traits of Common Oral Herbal Medicinal Products within Dhaka Metropolis
Aims: Present study endeavored to examine the growth and survival of microorganisms within 6 categories of oral herbal medicines commonly used by the community within Dhaka metropolis. Methodology: Samples were analyzed...