A new diagnostic model of primary open angle glaucoma based on FD-OCT parameters
Journal Title: International Journal of Ophthalmology - Year 2018, Vol 11, Issue 6
Abstract
"AIM: To build a clinical diagnostic model of primary open angle glaucoma (POAG) using the normal probability chart of frequency-domain optical coherence tomography (FD-OCT). METHODS: This is a cross-sectional study. Total 133 eyes from 133 healthy subjects and 99 eyes from 99 early POAG patients were included in the study. The retinal nerve fibre layer (RNFL) thickness parameters of optic nerve head (ONH) and RNFL3.45 scan were measured in one randomly selected eye of each subject using RTVue-100 FD-OCT. Then, we used these parameters to establish the diagnostic models. Four different diagnostic models based on two different area partition strategies on ONH and RNFL3.45 parameters, including ONH traditional area partition model (ONH-T), ONH new area partition model (ONH-N), RNFL3.45 traditional area partition model (RNFL3.45-T) and RNFL3.45 new area partition model (RNFL3.45-N), were built and tested by cross-validation. RESULTS: The new area partition models had higher area under the receiver operating characteristic (AROC; ONH-N: 0.990; RNFL3.45-N: 0.939) than corresponding traditional area partition models (ONH-T: 0.979; RNFL3.45-T: 0.881). There was no statistical difference among AROC of ONH-T, ONH-N, and RNFL3.45-N. Nevertheless, ONH-N was the simplest model. CONCLUSION: The new area partition models had higher diagnostic accuracy than corresponding traditional area partition models, which can improve the diagnostic ability of early POAG. In particular, the simplest ONH-N diagnostic model may be convenient for clinical application."
Authors and Affiliations
Ying-Zi Pan
Keywords
Related Articles
- EP ID EP484167
- DOI 10.18240/ijo.2018.06.09
- Views 50
- Downloads 0
Acute lens opacity induced by different kinds of anesthetic drugs in mice
"AIM: To study whether specific anesthetic drugs or tear layer evaporation was primarily responsible for the acute cataract and what the change of lens structure is in anesthetized mice. METHODS: Five groups were set up...
Incomplete capsulotomy and lens fragmentation during femtosecond laser-assisted cataract surgery associated with emulsified anterior chamber silicone oil: a case report
Letter to the Editor
Potential role of Müller cells in the pathogenesis of macropsia associated with epiretinal membrane: a hypothesis revisited
Pathophysiological explanations for metamorphopsia associated with retinal pathologies generally focus on photoreceptor organization disruption. However, the retinal microarchitecture is complicated, and we hypothesize t...
Altered perception of floaters in dementia causing self-inflicted injuries
Letter to the editor
Photorefractive keratectomy after cataract surgery in uncommon cases: long-term results
"AIM: To evaluate the efficacy and safety of the excimer laser correction of the residual refractive errors after cataract extraction with intraocular lens (IOL) implantation in uncommon cases. METHODS: Totally 24 patien...