A New Mathematical Model to Estimate the Effects of Lipid Induced Insulin Resistance on UPR mRNA Using Normal Distribution
Journal Title: International Journal for Research in Applied Science and Engineering Technology (IJRASET) - Year 2015, Vol 3, Issue 9
Abstract
In this paper we examined effects of lipid induced insulin resistance on insulin stimulation of endoplasmic reticulum (ER) stress. mRNAs of several ER stress markers were determined in fat biopsies obtained before and after 8-h hyperglycemic hyperinsulinemic clamping in 13 normal subjects and in 6 chronically insulin resistant patients with type 2 diabetes mellitus (T2DM). In normal subjects, hyperglycemia hyperinsulinemia increased after/before mRNA ratios of several ER stress markers. Lipid infusion was associated with inhibition of the PI3K insulin signaling pathway and with a decrease of hyperinsulinemia induced ER stress responses. In chronically insulin resistant patients with T2DM, hyperglycemic hyperinsulinemia did not increase ER stress response marker mRNAs. Single server queue with random accumulation level and analysis of the continuous time parameter process is used to find the effects of lipid induced insulin resistance on UPR mRNA with the help of normal distribution.
Authors and Affiliations
P. Senthil Kumar, K. Balasubramanian, A. Dinesh Kumar
Keywords
Related Articles
- EP ID EP21243
- DOI -
- Views 246
- Downloads 6
Cluster based Multipath routing to minimize delay, congestion and energy consumption in Wireless Sensor Network
Wireless Sensor Network (WSN) usually comprises of many sensors that detect any changes in the environment such as temperature, humidity, pressure, smokes, etc. Wireless Sensor Network is very Energy Confined networks....
Enhance web search results using user feedback sessions
Most search engines in use today present the user a single ordered list of documents matching the search query. Since most users do not browse past the first page of search results, this method of displaying results oft...
Low Profile Microstrip DGS – Based Wideband Slot Antenna for Wireless Applications
A low profile microstrip DGS-based wide band slot antenna for wireless applications is designed and simulated successfully. It is a defected ground structure - based antenna augmented with a rectangular slot and it is s...
Robust Video-based Face Recognition
In recent years, multi-camera networks have become increasingly common for biometric and surveillance systems. Multi view face recognition has become an active research area in recent years. In this paper, an approach f...
Comparative Study of Slosh Suppression Devices and Techniques for Liquid and Hybrid Rocket Propellant Tanks
The present study reviews and discusses about the undesirable phenomenon of propellant sloshing in propellant tanks of liquid and hybrid rocket engines. The occurrence of unexpected sloshing in propellant tanks usually...