A NEW METHOD DEVELOPMENT AND VALIDATION OF AXITINIB BULK AND PHARMACEUTICAL DOSAGE FORM BY USINGUV-VISIBLE SPECTROSCOPY AS PER ICH GUIDELINES
Journal Title: Indo American Journal of Pharmaceutical Sciences - Year 2018, Vol 5, Issue 3
Abstract
The objective of the present work was to develop a simple, efficient and reproducible spectrophotometric method for the quantitative estimation of Axitinib drug in its active pharmaceutical ingredient (API) form. The developed UV-Visible spectrophotometric method for the quantitative estimation of drug –Axitinib measurement of absorption at a wavelength maximum (λmax) of 260 nm using methanol as diluents. The method was validated as per the ICH guidelines. The proposed method can be successfully applied for the estimation of Axitinib in pharmaceutical dosage forms.The linearity dynamic range 10-70 μg/ml and effective mean percentage recoveries were 102.5% and LOQ, LOD values of Axitinib were found to be 1.62 and 5.04(µg/ml) Key Words: Axitinib, Method Development, Validation, UV-Visible spectrophotometry.
A CLINICAL STUDY ON ANTIBACTERIAL ACTIVITY OF TOOTHPASTES AGAINST DENTAL PLAQUE AND CARIES CAUSING BACTERIA
The present study was carried out to evaluate antibacterial activity of toothpastes, which were available in local market. A total 15 samples were collected for isolation of cariogenic bacteria. The bacterial strains wer...
DESCRIPTIVE STUDY KNOWING THE PATIENTS LOAD IN THE NEONATAL ICU AT THE TERTIARY CARE HOSPITAL LAHORE
Objective: To Know the Number of patients referred to tertiary hospital neonatal intensive care unit (NICU) in Lahore, disease model and outcome determination. Study Design: A descriptive study Location and duration: The...
EFFECTS OF FAST FOOD ON BMI AND PSYCHOLOGICAL HEALTH OF MEDICAL STUDENTS OF CENTRAL PARK MEDICAL COLLEGE LAHORE
Background: The trend of increasing fast food consumption among people especially among students is raising serious health related issues which includes obesity, increased BMI and other psychological issues. The objectiv...
THE PHARMACOLOGICAL EFFECTS OF HELIANTHUS ANNUUS- A REVIEW
Helianthus annuus was used as food and medicine worldwide. It was cultivated basically for its seeds, which give the world’s second most important source of edible oil. Phytochemical analysis showed that Helianthus annuu...
FORMULATION AND COMPARATIVE EVALUATION OF PANTOPRAZOLE BUCCAL PATCHES USING NATURAL AND SYNTHETIC POLYMER
Gastro-oesophageal reflux disease is a chronic condition of mucosal damage. GERD is caused by the regurgitation of stomach acid into the esophagus. Pantoprazole is a proton pump inhibitor which acts against GERD. This pr...