A Novel Approach in Fabrication and Characterization of Self Micro-Emulsified Tablets (SMET)
Journal Title: Saudi Journal of Medical and Pharmaceutical Sciences - Year 2016, Vol 2, Issue 9
Abstract
Abstract: In this study, concentration of cross carmelose sodium (CCS), microcrystalline cellulose (MCC) and maltose have optimized in self-micro emulsified tablet (SMET) of cinnarizine (CNZN), a piperazine derivative antihistaminic drug. The self-micro emulsified liquids (SELS) of CNZN were prepared with Linoleic acid, PEG 400 and Tween 80. The SMET of SELS were prepared by adsorption followed by compression phenomenon using CCS (A), maltose (B) and MCC (C) which were optimized through 23 factorial design considering responses like disintegration time (DT), time for 50 % (t50) and time for 80% (t80) of drug release. Droplet size and turbidity of disintegrated SMET emulsion sample was within 2.58 ± 7.48 to 4.84 ± 5.83 µm and 16.47 ± 6.35 to 27.10 ± 6.12 nephlometric turbidity units (NTU) respectively. The factors A and B were directly and C was inversely related with responses. Response surface methodology was used to predict the levels of the factors A, B and C required for obtaining an optimum formulation with minimum dissolution time. Observed responses were in close agreement with the predicted values of the optimized formulation, thereby demonstrating the feasibility of the optimization procedure in developing self-micro-emulsified tablet dosage forms. Keywords: Cinnarizine, Self-micro emulsified tablet, factorial design, Response surface methodology
Authors and Affiliations
Prasanta Kumar Biswal, Bibaswan Mishra, NiharRanjan Pani, Prasanna Kumar Dixit
Keywords
Related Articles
- EP ID EP388422
- DOI -
- Views 124
- Downloads 0
Synthesis and Evaluation of In-Vitro Antimicrobial Activity of Some Novel 2-Styryl-3-Substituted-(3H) ‒Quinazolin‒4‒one derivatives
(3H)‒quinazolin‒4‒ones were reported for enhanced antibacterial, antiviral, antifungal and antimalarial activities with aryl and styryl substituents at position two and three respectively. In the present work, synthesis...
Study of prevalence, socio-epidemiological factors and clinical profile of iron deficiency anaemia among pregnant rural population
Abstract: Nutritional anaemia in pregnant women continues to be one of the major public health challenges. Anaemia contributes to one fifth of the maternal deaths and large number of preterm deliveries and low birth we...
Hypoglycemic and Hypolipidemic Effects of Hoya parasiticaVariegata (Apocynaceae) and Crotalaria pallidaAiton (Fabaceae) Leaves in Aloxane-Induced Type 2 Diabetic Rats
Abstract:Traditional plant treatment for diabetes has produced a rising interest now a day. Therefore, the purpose of this study was to determine the hypoglycemic effect and hypolipidemic properties of the methanolic ext...
Topical ophthalmic in situ gels for ocular delivery: A recent Update
Abstract: Ocular drug delivery is challenging field to pharmaceutical scientists owing to the underlying anatomical, physiological and dynamic constraints put forth by the eye. Nonetheless, there is increasing need to ov...
Kinetic and Thermodynamic Properties of Immobilized Lettuce Protease and Its Role in Production of Novel Bile Binding and Tyrosinase Inhibitory Peptides from Some Plant Wastes
Abstract:This study was designed to compare the properties, kinetics and stability of the immobilized lettuce protease with the free one. We also aimed to test the use of the immobilized lettuce protease for the producti...