A novel protodioscin-enriched fenugreek seed extract (Trigonella foenum-graecum, family Fabaceae) improves free testosterone level and sperm profile in healthy volunteers
Journal Title: Functional Foods in Health and Disease - Year 2017, Vol 7, Issue 4
Abstract
Background: A novel, patent-pending 20% protodioscin-enriched extract has been developed in our laboratories from fenugreek seeds (Furosap®). We assessed the efficacy of Furosap® in 50 male volunteers (age: 35-65 years) on free and total increased testosterone levels, sperm profile, mental alertness, cardiovascular health, mood, libido, and quality of life. Methods: Furosap® (500 mg/day/subject) was administered to the 50 male volunteers over a period of 12 weeks in a one-arm, open-labelled study, to determine the efficacy on free and total testosterone levels, sperm profile and sperm morphology, libido and erectile dysfunction, mood and mental alertness and broad spectrum safety parameters. Institution Review Board approval was obtained for this study and the study was registered at the clinicaltrials.gov (NCT02702882). Results: A statistically significant increase in free testosterone levels were observed in these volunteers following supplementation of Furosap®. Sperm morphology, sperm counts, mental alertness, mood, cardiovascular health, and libido performance were significantly improved. Extensive blood chemistry analyses revealed broad spectrum safety. No significant changes were observed in serum lipid function, cholesterol, triglyceride, HDL and LDL levels, and hemogram. Conclusions: Results confirmed that this protodioscin-enriched extract from fenugreek seeds (Furosap) is safe and efficacious in boosting serum free testosterone levels, healthy sperm profile, mental alertness, cardiovascular health, and overall performance in male volunteers.
Authors and Affiliations
Debasis Bagchi, Anand Swaroop, Anuj Maheshwari, Narsingh Verma, Kiran Tiwari, Manashi Bagchi, Harry G. Preuss, Pawan Kumar
Keywords
Related Articles
- EP ID EP435098
- DOI 10.31989/ffhd.v7i4.326
- Views 147
- Downloads 0
In vitro investigation of orange fleshed sweet potato prebiotic potential and its implication on human gut health
Background: Some food ingredients (prebiotics) have been shown to promote a healthy gut by selectively stimulating growth/activity of beneficial gastrointestinal microbes and metabolites such as short chain fatty acids (...
Experimental Comparative Study of potential anxiolytic effect of Vitamin C and Buspirone in rats
Background: Anxiety disorders are the most common of all mental health problems. They are more prevalent among women than among men, and they affect children as well as adults. The aim of the current study is to evaluate...
Effects of selected antioxidant food extracts on postprandial glucose responses in healthy individuals
Background: Obesity and diabetes are highly prevalent in Western countries, and both conditions can be associated with impaired glucose control and hyperglycemia. Antioxidants have been identified as having the ability t...
Health Benefits of Dietary Tree Peony Seed Oil in a High Fat Diet Hamster Model
Background: Tree peony (Paeonia ostii) seed oil is rich in different unsaturated fatty acids, including monounsaturated fatty acids (MUFA), n-3 and n-6 polyunsaturated fatty acids (PUFA). Health benefits of this edible p...
Nutritional components of the sea cucumber Holothuria scabra
Background: Holothuria scabra is one of the most commercially important species found in the Pacific region. The sea cucumber extracts have been widely reported to have beneficial health effects. The aim of this study wa...