A Novel Topical Spray which Efficiently Provides Relief for Patients Suffering from Pruritus
Journal Title: Journal of Medical Science And clinical Research - Year 2018, Vol 6, Issue 3
Abstract
Background: Pruritus is defined as an “unpleasant sensation that elicits the desire or reflex to scratch”. It can occur without injury or disease, serves no apparent biological purpose and has no recognizable endpoint. It appears along with a number of skin and systemic diseases. Aim: to determine the benefit of a novel topical anti-pruritic spray containing Camellia sinensis and Tambourissa spp leaf polyphenol extracts, and enoxolone in patients with atopic dermatitis (AD), psoriasis, chronic idiopathic urticaria (CIU) or senile pruritus. Methodology: multicenter, prospective, observational, non-comparative study in 120 patients, 30 in each disease group. AD patients were to be aged between4monthsand 4years, psoriasis and CIU patients were to be of at least 18 years and senile pruritus patients of at least 65 years. At baseline and day 21, investigators assessed pruritus evolution using the 5-D pruritus scale, clinical efficacy and quality of life (QOL) through the Skindex-29 questionnaire in adults, the Infants' Dermatitis OOL Index and Family Dermatitis Index in children. Local tolerance was assessed. Results: The spray quickly and significantly provided relief from pruritus. The QOL of patients and the impact on their families significantly improved. A large majority of the patients appreciated the spray for its efficacy and its cosmetic properties. One adverse effect was reported in the AD group after 14 days of application, leading to the patient’s discontinuation. Local tolerance was good. Conclusion: The spray product significantly decreased pruritus severity, allowing an improvement in the daily life of patients with pruritic diseases.
Authors and Affiliations
Sandrine Virassamynaik
Keywords
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