A PHARMACEUTICAL APPROACH OF PEARL AS A BIOSAFE NANOMEDICINE
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2014, Vol 5, Issue 2
Abstract
Mukta or Pearl, a valuable gem is included in Ratna varga in most of the Ayurvedic texts. As far as the Ayurvedic Pharmaceutical Science is concerned, selection of raw material is the nucleus of the present study which is important step in standardization. Pearl is available in natural and cultured form. However the scarcity and price has limited the use of natural Pearl in medicine. Thus cultured Pearl was used for the study after thorough analysis using ancient as well as modern techniques like Microscopic study. Pearl was subjected to simple and special purification by Swedan in freshly prepared juice of lemon (Citrus acida Linn) and leaves of Jayanti (Sesbania sesban (Jacq.) W. Wight) respectively. Rose water was prepared as a modified infusion method so as to preserve its essential volatile oils. Mukta Pishti (MP) was prepared by triturating purified Pearl with Rose water per day 6 hours for 21 Days. To assure the quality of MP, Rasa-shastra quality control tests like Nishchandratva, Rekhapurnatva and Varitaratva were used. After MP was found to be in compliance with these tests, it was further analyzed using X-ray diffraction (XRD) analysis. Analysis of raw Pearl and MP revealed that both of them contain CaCO3 in Aragonite form. Determination of particle size was done by Dynamic light scattering (DLS) and Nanoparticle tracking analysis (NTA) for raw Pearl and MP respectively. The particle size was reduced greatly from114.019 µm to 62 nm. It may be concluded that raw Pearl and MP have no change in the form which can be attributed to the fact that Pishti preserves properties of Ratna. Also thorough trituration can reduce particle size up to nanometers. Thus it can validate the sukshmata of Pishti and can be correlated with concept of nanomedicine, essential for its quick and cellular activity.
Authors and Affiliations
R. C. Wavare , V. V. Kadam , S. M. Sheth , R. S. Sawant
Keywords
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- EP ID EP126182
- DOI 10.7897/2230-8407.050217
- Views 82
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