A Pharmacokinetic Analysis and Pharmacogenomic Study of 6-mercaptopurine
Journal Title: International Journal of Pharmaceutical Sciences and Developmental Research - Year 2015, Vol 1, Issue 1
Abstract
Background: The efficacy and safety of 6-mercaptopurine (6-MP) therapy rely on the concentration of its metabolites. The aim of the current study is the pharmacokinetic analysis of 6-MP and the detection of its metabolites as well as the role of Thiopurine S-methyl transferase (TPMT), the enzyme associated with 6-MP metabolism, as a pharmacogenomics biomarker.
Authors and Affiliations
A Vicha, T Katsila, E Giannopoulou, H Leontari, El Mubarak M El Mubarak, V Chondrou, GP Patrinos, HP Kalofonos, G Sivolapenko
Keywords
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- EP ID EP555589
- DOI 10.17352/ijpsdr.000002
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