A Pig Model for the Histological Analysis of Adipocytes after Co-injections of Autologous Fat with Fillers
Journal Title: International Journal of Surgery & Surgical Techniques - Year 2018, Vol 2, Issue 1
Abstract
Background: Currently, the rise of micro-plastic injections has become a significant trend in aesthetic medicine and safety issues among many materials such as botulinum toxin, hyaluronic acid, and injects able poly-L-lactic acid, have been discussed. However, there is not much discussion about the safety of these materials and autologous fat grafting. Therefore, we conducted this study in an attempt to investigate undiscovered interactions between autologous fat and botulinum toxin, hyaluronic acid or inject able poly-L-lactic acid. Materials and methods: The Lee-Sung pig model was used to analyze histological changes of Adipocytes after various injections such as mono injection of autologous fat, co-injection of hyaluronic acid with autologous fat, co-injection of poly-L-lactic acid with autologous fat and mono injection of botulinum toxin followed by autologous fat grafting, and to observe interactions between these materials and autologous fat. Results: Fibrosis easily occurred between the transplanted fat cells in the area where muscles were relaxed by botulinum toxin. No special interaction, but only mild fibrosis was found while hyaluronic acid and autologous fat were coadministered. The inject able poly-L-lactic acid caused granulomatous reactions, but these granulomas had no special histological interaction with transplanted fat cells. Conclusion: The results from our pig model showed that there was no histological interaction between autologous fat and hyaluronic acid/poly-L-lactic acid, which could be good implications for clinicians.
Authors and Affiliations
Jiun-Yit Pan, Hsiang-YA Wang, Chao-Yi Lai2, Wen-Tsao Ho*
Keywords
Related Articles
- EP ID EP745973
- DOI 10.23880/ijsst-16000116
- Views 1
- Downloads 0
A Pig Model for the Histological Analysis of Adipocytes after Co-injections of Autologous Fat with Fillers
Background: Currently, the rise of micro-plastic injections has become a significant trend in aesthetic medicine and safety issues among many materials such as botulinum toxin, hyaluronic acid, and injects able poly-L-l...
Perianal Abscess with Fistula in Ano Complicating as Basal Cell Carcinoma- A Rare Presentation
Introduction: Fistula in ano usually presents with pus discharge Perianal region, sometimes with mucus discharge. Malignant transformation in fistula in Ano very rare presentation1, and to assess preoperatively is almos...
Interrupted Versus Subcutaneous Continuous Skin Suture in Episiotomy Repair in Indian Urban Women: A Study
Introduction: Episiotomy also known as perineotomy, is a surgical incision of the perineum and the posterior vaginal wall generally done by a midwife or obstetrician during second stage of labor to quickly enlarge the o...
Septoplasty without Packing, Splints or Clip-Our Experience
Introduction: Septoplasty is a very commonly done surgery for deviated nasal septum in any Otorhinolaryngological department. Sometimes it may be combined with other procedures like FESS, synechiae release, AC polypecto...
A Study of Scrotal Radiology
Introduction: The diagnosis of the scrotal pathologies primarily rests upon clinical history and careful physical examination. Aims And Objectives: Looking at the immense importance of high resolution ultrasonography a...