A Population Pharmacodynamic Model for Lactate Dehydrogenase and Neuron Specific Enolase to Predict Tumor Progression in Small Cell Lung Cancer Patients
Journal Title: The AAPS Journal - Year 2014, Vol 16, Issue 3
Abstract
The online version of this article (doi:10.1208/s12248-014-9600-0) contains supplementary material, which is available to authorized users.
Authors and Affiliations
Núria Buil-Bruna, José-María López-Picazo, Marta Moreno-Jiménez, Salvador Martín-Algarra, Benjamin Ribba, Iñaki F. Trocóniz
The Pharmacokinetics and Interactions of Ivermectin in Humans—A Mini-review
Ivermectin is an antiparasitic drug with a broad spectrum of activity, high efficacy as well as a wide margin of safety. Since 1987, this compound has a widespread use in veterinary medicine and it use has been extended...
Drug inhibition of Gly-Sar uptake and hPepT1 localization using hPepT1-GFP fusion protein
An hPepT1-GFP fusion construct was made to study drug inhibition of dipeptide uptake and apical, basolateral, or subcellular hPepT1 localization. The hPepT1 stop codon was mutated by polymerase chain reaction and was sub...
Molecular modeling of mono- and bis-quaternary ammonium salts as ligands at the α4β2 nicotinic acetylcholine receptor subtype using nonlinear techniques
The neuronal nicotinic acetylcholine receptor (nAChR) has been a target for drug development studies for over a decade. A series ofmono- andbis-quaternary ammonium salts, known to be antagonists at nAChRs, were separated...
Inactivation of hepatic enzymes by inhalant nitrite—In vivo and in vitro studies
We examined the effects of acute isobutyl nitrite (ISBN) exposure on the activity of several hepatic enzymes. Two strains of adult male mice (Balb/c and C57BL/6) were exposed to 900 ppm ISBN or ambient air for 45 minutes...
Stochastic Process Pharmacodynamics: Dose Timing in Neonatal Gentamicin Therapy as an Example
The online version of this article (doi:10.1208/s12248-014-9715-3) contains supplementary material, which is available to authorized users.