A Possible Association of Sex Hormone-Binding Globulin with Weight Gain in the Valproic Acid-Treated Female Patients with Epilepsy
Journal Title: International Journal of Clinical Pharmacology & Toxicology(IJCPT) - Year 2014, Vol 3, Issue 1
Abstract
Weight gain is a common adverse consequence of treatment with valproic acid. Although a low sex hormone-binding globulin (SHBG) level was shown to be an independent risk factor for the development of metabolic syndrome and type 2 diabetes in the general population, there is presently no data available regarding the association between the SHBG level and valproic acid-induced weight gain. The association between the plasma SHBG level and being overweight was retrospectively investigated in 46 valproic acid-treated and 59 carbamazepine-treated patients with epilepsy. Among the female patients treated with valproic acid, the plasma SHBG levels tended to be negatively correlated with the gap between the body mass index value for each patient and the upper limit of the normal range (adjusted partial regression coefficient = -6.86, P = 0.041), and the SHBG levels were significantly lower in the overweight subjects than in the normal weight subjects (P = 0.001). These associations were not observed among the valproic acid-treated male patients or the carbamazepine-treated male and female patients. The plasma SHBG levels may be therefore associated with being overweight in the valproic acid-treated female patients.
Authors and Affiliations
Junji Saruwatari
Keywords
Related Articles
- EP ID EP201648
- DOI 10.19070/2167-910X-1400020
- Views 65
- Downloads 0
VKORC1 (-1639) Polymorphisms do not Affect Long-Term Stability of Anticoagulation with Warfarin
The extent of INR fall following vitamin K supplementation to patients on warfarin is related to VKORC1-1639G>A genotype, with those carrying the GG genotype demonstrating a significantly larger fall in INR compared to t...
Strategies for the use of SPE
Strategies for the use of SPE
CYP2B6 Genotype Guided Dosing of Propofol Anesthesia in the Elderly Based on Nonparametric Population Pharmacokinetic Modeling and Simulations
Objective: The primary aim of this article is to test the hypothesis that nonparametric pharmacometric modeling will accurately identify CYP2B6 genotype subgroups based on data from a study that reported results based on...
Body Fluid Extraction of Toxic Dental Materials Made From Methyl Methacrylate And HPLC Analysis Combined With Automated SPE
Methyl methacrylate polymer (PolyMMA) is widely used as the composite resin for the dental plate. During the preparation process of PolyMMA by the polymerization reaction, benzoylperoxide (BPO) and N,N’-dimethyl p-toluid...
Effect of Some Anti hypertensive Drugs on Alkaline Phosphatase and DNA of Mice
The dislipidemias are a risk factor well recognized of the cardiovascular diseases and constitute a problem of public health. A descriptive study in 150 patient elders of 30 years with diagnosis of Izquemic Cardiopathyes...