A Possible Functional Role of HSP27 as a Molecular Chaperone of Wnt1 in Cell Differentiation of Pleomorphic Adenomas
Journal Title: International Journal of Dentistry and Oral Science (IJDOS) - Year 2016, Vol 3, Issue 10
Abstract
The study focused on the differentiation of parenchymal tumor cells in pleomorphic adenomas. According to ourprevious published data, Wnt1 is involved in squamous differentiation of basaloid cells in solid nests and small cuboidal cells in duct-like structures during cell differentiation in pleomorphic adenoma. Furthermore,HSP27 sometimes act as a molecular chaperone in neoplastic cells. Thus, immunohistochemistry was performed using Wnt1 and HSP27. A total of 30 cases of pleomorphic adenoma were re-evaluated histologically and categorized based on WHO classification. The mean age of the patients is 51.5 years consisting of 13 males and 17 females. Fourteen tumors were located in the palate, 5 in the parotid gland, 4 in the mandibular gland, 3 in the upper lip, 3 in the buccal mucosa and 1 in other region. Wnt1 and HSP27 expressions were observed under a light microscope. Wnt1 was detected in almost all tumor cells. The basaloid cells with squamous metaplasia and small cuboidal cells forming duct-like structures were strongly positive to Wnt1. The immunofluorescent staining pattern of Wnt1 and HSP27 was consistent with previous results. The results suggest that Wnt1 and HSP27 are involved in tumor cell differentiation of basaloid cells in solid nests and small cuboidal cells in duct-like structures. Moreover, HSP27 is highly involved in cell differentiation such as the formation of squamous metaplasia in solid tumor nests. Since HSP27 expression was similar to Wnt1, it can be inferred that HSP27 works as possible molecular chaperone in Wnt1 signaling
Authors and Affiliations
Toshiyuki Kawakami
Keywords
Related Articles
- EP ID EP201301
- DOI 10.19070/2377-8075-1600069
- Views 174
- Downloads 0
Evolution of Dental Ceramic from the Platinum Foil to CAD-CAM Technologies: Review
New ceramic materials and novel fabrication methods have been developed and introduced in dentistry with the aim to improve the longevity of dental ceramic restorations and to extent their use for more demanding clinical...
Palatal Rugae Patterns Among a Sudanese Population Sample
Palatal rugae patterns can have a significant role in forensic identification when it is difficult to use the normal identification methods. This study aimed to identify the morphological patterns of palatal rugae in a s...
A Radiographic Study of Non-Syndromic Congenitally Missing Teeth in Permanent Dentition of Nigerian Dental Patients
Congenitally missing permanent teeth was evaluated on orthopantomograms of 611 apparently healthy patients, aged 10 to 25 years at a specialist dental clinic in Lagos, Nigeria. The prevalence of congenitally missing teet...
Evaluation of the Erosive Effect of Chewing Aspocid versus its Soluble Form on Micro Hardness of Primary Teeth Enamel in Heart Disease Children. (In Vitro-Study)
Background: Aspocid 75 mg chewing tablets (pH = 3) is the usual drug used in children with heart disease, this acidic medicine is available in Egyptian markets and accessible by the public. This may lead to increase thei...
Optical Coherence Technology Detects Early Signs of Peri-implant Mucositis in the Minipig Model
Background: Peri-implant mucositis defines the inflammation of gingival tissue surrounding osseous integrated implants without destruction of supporting bone. Untreated mucositis may develop into peri-implantitis with ir...