A preliminary perusal of ACE I/D polymorphism with adiposity traits and blood pressure among the AO NAGAS: Does gender-dependent gene expression matter?
Journal Title: International Journal of Medical Research & Health Sciences (IJMRHS) - Year 2016, Vol 5, Issue 12
Abstract
This study aims to evaluate the association of gender-dependent expression of angiotensin converting enzyme gene polymorphism (I/D) with adiposity markers and blood pressure among AoNagas.57AoNagas[Males (n) =26; Females (n) = 31; Mean Age: 30.56±7.5 and 31.9 ±8.3 1]residing in Delhi were included in this cross sectionalstudy. Anthropometric measurements and blood pressure were taken using standardized techniques. Adiposity indices viz., BMI, WHR and WHtR were computed. Body fat percentage was assessed by bioelectricimpedance technique using Tanita Body composition analyzer (T-6360). Venous blood samples were withdrawn for DNA extraction and genotyping of ACE gene (I/D) polymorphism was established by polymerase chain reaction (PCR). In female participants with DD homozygote, risk of both general and central obesity as depicted by BMI, body fat percentage, WC, WHR and WHtR were higher than ID heterozygote. Risk of hypertension was found to be greater among males with DD homozygote rather than females with DD homozygote. In males, obesity was not found to be associated with hypertension in either DD or ID genotypic variants of ACE. Whereas, in females obesity was significantly and positively correlated with hypertension in both DD and ID genotype. DD homozygous form of ACE is linked with both obesity and blood pressure in females and only with blood pressure in males. This genotype-by-gender interaction gives us a facet in understanding the complex genetic basis of adiposity and blood pressure phenotypes.
Authors and Affiliations
Imkongtenla Pongen| Department of Anthropology, University of Delhi-110007, India, Meenal Dhall| Department of Anthropology, University of Delhi-110007, India, Corresponding Email: satwanti@yahoo.com, Satwanti Kapoor| Department of Anthropology, University of Delhi-110007, India
Investigating the Effect of using Mentha pulegium Powder in Controlling Non-Bacterial Diarrhea in Adults
Diarrhea is the second leading cause of morbidity in developing countries and many factors are responsible for it including infectious and non-infectious. This study aimed to investigating the effect of using Mentha pul...
Evaluation of heavy metals level (arsenic, nickel, mercury and lead) effecting on health in drinking water resource of Kohgiluyeh county using geographic information system (GIS)
This study was conducted to determine the amount of heavy metals (Arsenic, Nickel, Mercury, and Lead) in drinking water resource of Kohgiluyeh County using Geographic Information System (GIS). This cross-sectional study...
Oral Mycotic Flora and Its Association with pH, OHI-s & DMFT indexes in students of Mazandaran University of Medical Science in 2015
Candida fungi is grouped in the fermenting fungi strain. Candida types are usually the normal flora and mostly get pathogens in immune system deficiency. The most common place of candidiasis infection is in the mouth. O...
EVALUATION OF AGGREGATIBACTER ACTINOMYCETEMCOMITANS LEVELS IN LOCALIZED AGGRESSIVE PERIODONTITIS BEFORE AND AFTER PERIODONTAL SURGERY
Background The role of microorganisms in the etiology of periodontal disease is well understood. The association of specific organisms in the pathogenesis of periodontal disease was established by the specific plaque h...
Correlation of Frequency of Pseudomonas Aeruginosa and Exos & Exou Genes and Their Antibiotic Sensitivity Pattern in Specimen Isolated from ICU Ward
Pseudomonas aeruginosa is a cause of nosocomial infections that can be destroyer by antibiotic-resistant strains. This study conducted to determine the antibiotic susceptibility pattern and distribution of exoU and exoS...