Critical Variables Associated with Nonbiodegradable Osmotically Controlled Implants

Osmotically controlled implants yield precise zero-order drug delivery kinetics and are utilized in a number of applications. The implants deliver drugs for extended periods (weeks to years) and exhibit good in vivo/in v...

Characterization of Nanoporous Surfaces as Templates for Drug Delivery Devices

Bare silicon wafers, gold-coated silicon wafers, and nanoporous gold-coated silicon wafers were obtained from Nanomedsystems, Charlottesville, VA, USA (formerly Setagon, Inc.). A bare metal stent (Palmaz-Schatz®...

Kinetics of hallmark biochemical changes in paclitaxel-induced apoptosis

Apoptosis is associated with cascades of biochemical changes, including caspase activation, cleavage of poly-ADP-ribose polymerase (PARP), and fragmentation of genomic DNA. Knowledge of the kinetics of these changes in d...

Workshop Report: Crystal City V—Quantitative Bioanalytical Method Validation and Implementation: The 2013 Revised FDA Guidance

In September 2013, the FDA released a draft revision of the Bioanalytical Method Validation (BMV) Guidance, which included a number of changes to the expectations for bioanalysis, most notably the inclusion of biomarker...

Effect of chloroquine on phagolysosomal fusion in cultured guinea pig alveolar macrophages: Implications in drug delivery