A Priori Prediction of Tumor Payload Concentrations: Preclinical Case Study with an Auristatin-Based Anti-5T4 Antibody-Drug Conjugate

Journal Title: The AAPS Journal - Year 2014, Vol 16, Issue 3

Abstract

The online version of this article (doi:10.1208/s12248-014-9576-9) contains supplementary material, which is available to authorized users.

Authors and Affiliations

Dhaval K. Shah, Lindsay E. King, Xiaogang Han, Jo-Ann Wentland, Yanhua Zhang, Judy Lucas, Nahor Haddish-Berhane, Alison Betts, Mauricio Leal

Keywords

Related Articles

Sequential Bioequivalence Approaches for Parallel Designs

The online version of this article (doi:10.1208/s12248-014-9571-1) contains supplementary material, which is available to authorized users.

Modeling Subpopulations with the $MIXTURE Subroutine in NONMEM: Finding the Individual Probability of Belonging to a Subpopulation for the Use in Model Analysis and Improved Decision Making

In nonlinear mixed effects modeling using NONMEM, mixture models can be used for multimodal distributions of parameters. The fraction of individuals belonging to each of the subpopulations can be estimated, and the most...

Quantitative comparison of functional screening by measuring intracellular Ca2+ with radioligand binding at recombinant human dopamine receptors

The purpose of this study was to test whether screening at dopamine receptors performed with a recently described functional assay for G-protein coupled receptors (GPCRs) provides data that correlate significantly with r...

Population Pharmacodynamic Modeling of Hyperglycemic Clamp and Meal Tolerance Tests in Patients with Type 2 Diabetes Mellitus

In this study, glucose and insulin concentration–time profiles in subjects with type 2 diabetes mellitus (T2DM) under meal tolerance test (MTT) and hyperglycemic clamp (HGC) conditions were co-modeled simultaneou...

Delivery of Macromolecules Using Arginine-Rich Cell-Penetrating Peptides: Ways to Overcome Endosomal Entrapment

Arginine-rich cell-penetrating peptides (AR-CPPs) are very promising tools for the delivery of therapeutic macromolecules such as peptides, proteins, and nucleic acids. These peptides allow efficient internalization of t...

Download PDF file
  • EP ID EP681083
  • DOI  10.1208/s12248-014-9576-9
  • Views 36
  • Downloads 0

How To Cite

Dhaval K. Shah, Lindsay E. King, Xiaogang Han, Jo-Ann Wentland, Yanhua Zhang, Judy Lucas, Nahor Haddish-Berhane, Alison Betts, Mauricio Leal (2014). A Priori Prediction of Tumor Payload Concentrations: Preclinical Case Study with an Auristatin-Based Anti-5T4 Antibody-Drug Conjugate. The AAPS Journal, 16(3), -. https://europub.co.uk/articles/-A-681083