A Profile of Microbial Isolates and Antibiotic Susceptibility Patterns in Neonatal Sepsis at a Tertiary Care Centre in South India - A Post HOC Analysis
Journal Title: Progressing Aspects in Pediatrics and Neonatology - Year 2018, Vol 1, Issue 5
Abstract
Background: Neonatal sepsis is a common problem in Neonatal intensive care units. Neonatal sepsis is classified as early onset and late onset based on the time of occurrence of clinical symptoms in the neonate. Organisms causing sepsis in neonates vary from unit to unit and from time to time within the same unit. Study of microbial pattern and their antibiotic sensitivity pattern is essential part of managing septic neonates. Methods: The study was carried out in Govt Kilpauk medical college hospital between October 2010 to October 2012 Results: A total of 207 newborns with clinical sepsis were admitted. Blood culture was positive in 88 out of the 207 cases (42.51%) Klebsiella is the commonest organism causing sepsis (45%) in our Neonatal Intensive Care Unit. Other gram-negative isolates included Escherichia Coli (31%), Pseudomonas (6%), Enterobacter (1%) and Acinetobacter (2%). The Gram-positive organisms grown were Coagulase Positive and Coagulase negative Staphylococci (8%), Group B Beta Hemolytic Streptococcus (5%) and Enterococcus (2%). Late-onset sepsis cases were found to be 1.5 times higher than early-onset sepsis. Out of 88 cases, 34(38.64%) had early-onset sepsis and 54(61.36%) had late-onset sepsis. Conclusion: A insight knowledge of the microbial isolate and their sensitivity pattern in Neonatal intensive care unit is essential in preventing mortality. The commonly pathogens isolated in the study are found to be resistant to the commonly used antibiotics.Neonatal sepsis is a clinical syndrome of bacteremia with systemic signs and symptoms of infection in the neonatal period [1,2]. Neonatal sepsis is broadly classified into two types namely early onset sepsis and late onset sepsis. Early onset sepsis is caused by organisms prevalent in the maternal genital tract, labour room or operating theatre, while late onset sepsis usually results from nosocomial or community-acquired infection. Sepsis is one of the major causes of mortality in neonates. According to World Health Organization (WHO) estimates, there are about 5 million neonatal deaths a year, with 98% occurring in developing countries [3]. The incidence of neonatal sepsis according to the data from National Neonatal Perinatal Database (NNPD, 2002-03) is 30 per 1000 live births and contributes to 19% of all neonatal deaths [4]. Neonatal sepsis is caused by a variety of Gram +ve as well as Gram -ve bacteria and rarely by fungus and yeast [5]. Diagnosis of neonatal sepsis clinically is difficult as the symptoms and signs are non-specific.
Authors and Affiliations
Santosh Kumar Kamalakannan, NC Manikandan, Sankavi Santosh Kumar
Keywords
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- EP ID EP580534
- DOI 10.32474/PAPN.2018.01.000123
- Views 60
- Downloads 0
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