A PROSPECTIVE CLINICO-PATHOLOGICAL STUDY OF ORAL LESIONS AND DIAGNOSTIC CORRELATION BETWEEN BRUSH CYTOLOGY AND HISTOPATHOLOGY
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2018, Vol 7, Issue 14
Abstract
BACKGROUND Oral carcinoma is the 6th most common malignancy in western world and accounts for more than 40% cancers in the world. Normally, the standard practice to confirm the presumed clinical diagnosis is to take punch biopsy of the lesion. But exfoliative cytology being a non-invasive procedure has a better patient compliance. Aims and Objectives- To evaluate the clinical profile of the patients of oral mucosal lesions and to find the diagnostic correlation between brush cytology and histopathology of these oral mucosal lesions as well as to see the histopathological pattern of these lesions and to establish the factors which are usually causative to such malignant oral lesions. MATERIALS AND METHODS 60 cases with oral mucosal lesions were included in the study. All patients underwent oral brush cytology and punch biopsy. Sensitivity, specificity, positive and negative predictive values were calculated. Cytopathology and histopathology of the lesions were compared. RESULTS The incidences of oral cancer were very high among the age group of 42 - 50 years. Males were more affected (M: F 3.2: 1) and the most common site involved was the tongue. The sensitivity, specificity, positive and negative predictive values for malignant lesions were 92.7%, 80%, 98% and 50%. Statistical analysis showed p < 0.05, suggesting that there is significant association between brush cytology and histopathology in assessing clinically premalignant and malignant lesions. CONCLUSION Oral brush cytology is an important screening tool for early diagnosis of oral cancer and is the key factor for its effective management. The fact that it is painless, easy to perform, has better patient compliance, has high specificity in both malignant and premalignant lesions makes it an ideal screening test.
Authors and Affiliations
Aparaajita Upadhyay, Mundra R. K
Keywords
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- EP ID EP414313
- DOI 10.14260/jemds/2018/384
- Views 100
- Downloads 0
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