A Prospective Comparative Study of Efficacy of Zoledronic Acid Vs Teriparatide On Bone Mineral Density Via Dexa Scan in Post Menopausal Osteoporosis
Journal Title: International Journal of Medical and Health Sciences - Year 2017, Vol 6, Issue 3
Abstract
Aim: To study and compare the effect of zoledronic acid and teriparatide on bone mineral density in postmenopausal women with osteoporosis. Material and methods: 100 postmenopausal patients having BMD score <-1 were selected from the outpatient department of Gynecology, S.N. Medical College, Agra. The study was undertaken in collaboration with Orthopedician. Randomly divided into two groups.Group-A: 50 patients given 5 mg Iv zoledronic acid infusion, 2 such doses were given at 6 months interval.Group-B: 50 patients given 20 µg/day teriparatide by subcutaneous injection for 3 months.Follow up at 12 months and BMD score are compared. Results: There was significant increase in BMD in both the groups over a period of one year but increase was more significant in teriparatide group (8 to 10%) as compared to 4-6% increase in zoledronic acid group. Clinical symptoms improved in both groups with fewer side effects in teriparatide group. Conclusion: Both teriparatide and zoledronic acid are good options for management of postmenopausal osteoporosis with teriparatide having better clinical efficacy and less side effects though it is expensive and requires daily administration.
Authors and Affiliations
Meenal Jain, Amit Agarwal, Ruchika Garg
Keywords
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