A Prospective, Double Blind, Randomized Study to Compare the Analgesic Effect of Oral Clonidine and Oral Pregabalin for Perioperative Pain in Lower Abdominal Surgeries
Journal Title: INTERNATIONAL JOURNAL OF SCIENTIFIC STUDY - Year 2018, Vol 6, Issue 6
Abstract
Background and Aims: The aim of this study is to compare the post-operative analgesic properties of oral clonidine versus oral pregabalin used preemptively. Materials and Methods: Our study included 64 patients of both sex, aged between 18 and 50 years of ASA Grade I and II, scheduled for lower abdominal surgeries. Group A patients were provided with oral clonidine in a dose of 200 mcg 45 min before the scheduled operation. Group B patients were given oral pregabalin in a dose of 150 mg 45 min before the schedule time of operation. Various parameters were recorded such as intra- and post-operative hemodynamics, post-operative visual analog scale scores, time to first rescue analgesic, and mean doses of analgesic required in the post-operative period and the associated side effects of the drugs used in the study. Results: Group A had least intraoperative cardiovascular stability and Group B had best intraoperative and post-operative cardiovascular stability. Group B patients showed maximum post-operative analgesia requirement. Overall, side effects were highest in Group B. Conclusion: It could be concluded that the use of preemptive pregabalin provides excellent hemodynamic stability while superior analgesia, less post-operative analgesic requirement was observed with the preemptive use of oral clonidine.
Authors and Affiliations
Veena Kachhwah, Sushant Rahal, Neeraj Narang
Keywords
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