A PROSPECTIVE OBSERVATIONAL STUDY OF THE CLINICOPATHOLOGICAL PROFILE, EPIDEMIOLOGICAL RISK FACTORS AND FALLOPIAN TUBE MUCOSAL INVOLVEMENT IN OVARIAN CANCER
Journal Title: Journal of Evidence Based Medicine and Healthcare - Year 2017, Vol 4, Issue 1
Abstract
BACKGROUND Many of the ovarian tumours traditionally thought to be of ovarian origin is now thought to primarily originate in other pelvic organs and ovarian involvement is actually secondary. MATERIALS AND METHODS A prospective observational study was conducted in the Department of Obstetrics and Gynaecology, Government Medical College, Kozhikode, over a period of 10 months from January 2013 to October 2013. All cases of carcinoma ovary operated and specimen submitted for histopathology examination with no gross involvement of fallopian tubes were included in the study. All cases where specimen showed gross involvement of fallopian tubes or adherence of the fallopian tubes to the ovary were excluded. Bilateral salpingectomy specimens from women undergoing surgery for reasons other than ovarian, tubal or peritoneal malignancy were taken as controls. General information regarding the patients was collected. Investigation results were analysed. Histopathology examination of the specimen was done. Fallopian tube was examined by SEE-FIM (sectioning and extensive examination of fimbrial end) protocol and was submitted for p53 and Ki67 studies. RESULTS Pain was the most common presenting symptom. Ultrasound was suggestive of ovarian malignancy in majority. Tubal involvement was noted in 35% cases and 27% controls. 61% of cases were above 45 years of age. 60% of cases had not undergone tubal ligation. Family history of malignancy was more among cases. CONCLUSION Fallopian tube mucosal involvement was noted in 35% of cases and 30% of controls. These lesions can be considered as precursor lesions in carcinoma ovary. However, further studies with larger sample size is needed. Tubal ligation not done was found to be a significant risk factor for ovarian carcinoma. Age of menopause above 48 years and family history of malignancy were associated with increased risks. Incidence of ovarian carcinoma showed an increase with increasing age.
Authors and Affiliations
Suneetha Kalam, Nisha Anand, Rabiyabi V
Keywords
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- EP ID EP210969
- DOI 10.18410/jebmh/2017/4
- Views 182
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