A prospective observational study to evaluate the pattern of pituitary dysfunction in patients with acute phase of subarachnoid haemorrhage.
Journal Title: International Journal of Medical Science and Innovative Research (IJMSIR) - Year 2018, Vol 3, Issue 11
Abstract
Introduction: SAH has been predicted as a risk for hypothalamic–pituitary dysfunction. Pattern of hormonal impairments has been shown to differ substantially. Cause of these functional problems remains, at least in part, unclear and many of these symptoms are similar to those occurring in patients with untreated hypopituitarism. Aim and objectives: The present study was performed to observe the pattern of pituitary dysfunction in patients with acute phase of subarachnoid haemorrhage, who were admitted in the intensive care unit of a tertiary care hospital. Materials and Methods: Anterior pituitary hormones were analysed in 98 patients within 72 h after spontaneous SAH. Out of 98 patients in our study, 29 (29.5%) patients had no hormonal dysfunction, 21 (22%) patients had single hormonal dysfunction, 26 (26%) patients had abnormality of two hormones and 21 (22%) patients had more than two hormonal dysfunction. found subclinical hypothyroid in 9 patients with mean TSH levels of 6.16±1.41 µIU/ml. In 4 patients TSH levels were >10 µIU/ml. 24 male patients were having low testosterone levels. Low estradiol was detected in 9 (30.8%) female patients. Conclusion: Our study confirmed that anterior pituitary hormonal deficiency occur in a substantial number of patients at initial stage of sub arachnoid haemorrhage, whether this occurs later on needs to be followed and studied. Thus it is important to evaluate these patients continuously with periodic endocrine examination and follow up.
Authors and Affiliations
Mehraj Ud Din
Keywords
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