A Prospective, Randomized Controlled Trial of Noninvasive Ventilation in Acute Exacerbation of Asthma in Children
Journal Title: Journal of Medical Science And clinical Research - Year 2017, Vol 5, Issue 11
Abstract
Objective: To compare the benefits of noninvasive ventilation (NIV) plus standard therapy vs standard therapy alone in children with acute exacerbation of asthma. Design: Randomized control trial. Setting: Tertiary care Pediatric Intensive Care Unit (PICU), duration of study from October 2014 to September 2016. Participants: Three month to twelve years with acute severe asthma (<24 hours) with initial Becker Score >7 were eligible for this study. Interventions: The study group received NIV under inspiratory positive airway pressure ranging between 10 cm - 18 cm H2O, expiratory positive airway pressure between 4 cm - 12 cm H2O. Vital signs, PO2, PCO2, pH, SPO2 , becker score were recorded at the start, 1, 2, 4, 12, 24, and 48 hrs into the study. Result: Heart rate after four hour and twelve hour and respiratory rate after two hour of treatment were significantly lower compared with admission (p = 0.0001 and p = 0.0294, respectively). With NIV, PO2 at four hour, SPO2 at two hour improved significantly. The endotracheal intubation was significantly lower (22%) in the NIV group than in the control group (45%; p = 0.01698).There was significant difference in length of stay in PICU (p= 0.0109) and hospital (p = 0.0115). Conclusion: NIV seems to afford these children protection from endotracheal intubation and reduced in length of stay in PICU and hospital.
Authors and Affiliations
Dr Sudipta Ghorai MBBS
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