A Prospective Study Comparing Two Clinical Doses of Fentanyl as an Adjuvant to Isobaric Ropivacaine 0.75% in Intrathecal Block
Journal Title: INTERNATIONAL JOURNAL OF SCIENTIFIC STUDY - Year 2018, Vol 6, Issue 4
Abstract
Aim: Subarachnoid block is the simple technique of regional anesthesia commonly employed for infraumbilical surgeries. Neuroaxial administration of fentanyl along with local anesthetics improves the quality of intraoperative analgesia, reduces the need for sedation, and also provides post-operative pain relief for longer duration. This study was designed to compare the two doses of fentanyl with isobaric ropivacaine in spinal anesthesia in terms of analgesic efficacy, hemodynamic stability, and effect on sensory and motor characteristic. Method: This prospective randomized, double-blind study involving 20 patients in each group. Group A received injection isobaric 0.75% ropivacaine 4.0 ml + 1 ml cerebrospinal fluid (CSF), Group B received injection isobaric 0.75% ropivacaine 4.0 ml + fentanyl 12.5 μg (0.5 ml) + CSF 0.5 ml, and Group C received injection isobaric 0.75% ropivacaine 4.0 ml + fentanyl 25 μg (0.25 ml) + CSF 0.75 ml. On set time, onset of sensory and motor block, highest dermatomal level blocked, duration of sensory and motor block, and quality of motor block were noted. Vital parameters and adverse effects were also noted perioperatively. Data analysis was done with unpaired t-test, one-way ANOVA, and post hoc Tukey test. Results: Onset of sensory block was comparable. Onset of motor block, duration of sensory, and motor block were statistically prolonged in Group B and Group C. Conclusion: About 12.5 μg fentanyl with isobaric ropivacaine provides better hemodynamics, early onset of sensory and motor block, and prolonged period of analgesia without undesirable side effects.
Authors and Affiliations
Ashwin Beohar, Meena Singh, Vibha Mishra
Keywords
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