A Prospective Study of Adverse Drug Reactions to Antiretroviral Therapy in a Tertiary Care Hospital at Allahabad, Uttar Pradesh
Journal Title: International Journal of Contemporary Medical Research - Year 2018, Vol 5, Issue 11
Abstract
Introduction: Human Immunodeficiency Virus has a significant disease burden globally. India has a large proportion of the global HIV infected patients. The state of Uttar Pradesh had 7500 new cases in 2015. Antiretroviral therapy is the cornerstone of treatment of HIV. These drugs are highly toxic and lead to diverse adverse drug reactions. The present prospective study was done to study the occurrence of adverse drug reactions and analyse the associated factors. Material and Methods: The present study was conducted at Antiretroviral Therapy Centre, Swarup Rani Nehru Hospital at Allahabad, Uttar Pradesh. Patients were enrolled for two months and followed up monthly over a period of six months. A pretested interview schedule was administered to the study subjects. Information regarding socio-demographic profile, drug regimen and occurrence of adverse drug reactions was collected. Causality assessment was done by Naranjo’s criteria. Bivariate and multivariate logistic regression was done to analyse the association of selected variables with the occurrence of adverse reactions. Results: This study enrolled 163 participants and 152 participants completed the study. During the study period, 94 participants reported occurrence of at least one ADR. A total of 334 ADRs were reported among them. TLE regimen constituted 66.4% of adverse reactions. Central nervous system was most commonly involved (34.4%). By Naranjo’s scale, majority of ADRs (61.6%) were categorised as “possible”. Multi-variate analysis showed statistically significant association of occurrence of ADR with higher clinical staging of the patient. Conclusion: Tenofovir based regimen was most commonly associated with ADRs. Rigorous monitoring is essential to prevent future events and improve safety.
Authors and Affiliations
Arkapal Bandyopadhyay, Rakesh Chandra Chaurasia, Rakesh Kumar Yadav, Sarika Palepu
Keywords
Related Articles
- EP ID EP432893
- DOI -
- Views 97
- Downloads 0
A Study on Echocardiographic Evaluation of Pericardial Diseases
Introduction: Pericardial effusion was a diagnostic enigma before the advent of echocardiography, both in developed and developing countries, more so in poorer countries.Advent of M-Mode and 2D-Echocardiography has revol...
Conventional and Modified Papilla Preservation Flap (PPF) using Bone Graft and Platelet Rich Fibrin (PRF): an Attempt of Management of Soft Tissues in an Esthetic Zone
Introduction: Esthetics is of prime concern in today’s sophisticated and modernised society. Esthetics is the science of beauty and encompasses almost every field of dentistry. An ideal periodontal therapy must necessari...
Turnaround Time For Issuing Blood Products in Emergency-A Prospective Real Time Study in a Regional Blood Transfusion Centre
Introduction: Turnaround time (TAT) is one of the key performance indicator of laboratory services. In transfusion services it is more important due to involvement of emergency cases often. We analyzed the TAT in issuing...
Use of Proseal LMA in a Patient of Fracture Cervical Vertebra Presenting for Non Spinal Surgery - Are We Justified?
Introduction: Airway management in a patient of cervical spine injury is an audacious but a rewarding task. The key to successful management of these patients is attention to head positioning and stabilization during ini...
Clinical Profile and Management Outcome of Paediatric Penetrating Ocular Trauma in a Tertiary Eye Centre in Eastern India
Introduction: Globally an estimated 70 million blind years are caused by childhood blindness. This study was done to evaluate the pattern, causes and treatment outcome of penetrating ocular trauma in pediatric age group....