A Prospective Study on Placental Changes in Pre-Eclamptic Women and Correlation of Severity of Hypertension with Placental Changes and their effect on Neonatal Outcome
Journal Title: Journal of Medical Science And clinical Research - Year 2018, Vol 6, Issue 3
Abstract
Context: Placenta forms a functional unit between mother and fetus. Preeclampsia is regarded as a risk factor in pregnancy and it leads to placental insufficiency. This, in turn causes both maternal and fetal morbidity and mortality. The present study intends to compare morphological and histological changes of placenta in pre-eclampsia and correlate severity of hypertension with histopathological changes of placenta and correlate these changes with perinatal outcome. Study Design: A descriptive type of study. Place and period of study: Department of Pathology, Anaesthesiology and Gynecology, S.S.Medical College, Gandhi Memorial Hospital, Rewa(M.P.) from 1stjuly 2016 to 30th June 2017. Materials: 200 cases were taken. 90 cases were of Mild Preeclampsia, 78 cases were of Moderate and 32 cases were of Severe Preeclampsia were taken for this study. Method: Samples were grouped in three groups on the basis of severity of Preeclampsia. All samples were studied morphologically and histologically. Result: To summarise the results of this study was the birth weight and placental weight significantly decreases from moderate group of preeclampsia and also placental infarction, calcification, syncytial knot, basement membrane thickening and fibrinoid necrosis significantly increases from the moderate preeclampsia and is highest in severe preeclampsia. Conclusion: In the present study all the morphological and histopathological variants of placenta are affected very less in cases of mild preeclampsia but there is a significant increase in the changes from the moderate group and the perinatal outcome was also comparatively poor in this group. Till now, antihypertensives are started when B.P. >160/110 mmhg, means from severe preeclampsia .But on the basis of the results of this study we recommend early initiation of antihypertensive treatment, it will be helpful in improving the perinatal outcome
Authors and Affiliations
Dr. Subhash Kumar Agrawal
Keywords
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