A random comparative therapeutic trial of oral nifedipine v/s topical 5% minoxidil gel in patients of perniosis at a tertiary care center of North-western India
Journal Title: IP Indian Journal of Clinical and Experimental Dermatology - Year 2018, Vol 4, Issue 1
Abstract
Introduction Perniosis chilblain is a highly common prolonged cold induced skin disorder a very common nuisance in general skin OPD of northern parts of India where winters are long and prolonged and temperatures dip to almost zero Various treatment modalities have been tried for its treatment on time and again but none of the treatments have given optimum fast results We conducted a study on perniosis in peak winters at one of the tertiary care center of the western IndiaAim and Objectives To study and compare the efficacy of oral nifedipine vs topical 5 minoxidil Gel in perniosisMethod The patients clinically fitting in to the diagnosis of perniosis were divided randomly in to two groups Necessary clinical examination and investigations were carried out to find out any other associated ailment including pregnancy Group A was given oral nifedipine 10 mg three times daily and Group B was given topical minoxidil 5 Gel applied twice daily topically Irrespective of the group all the patients were given oral antihistaminics Both clinical and subjective responses were noted on day 3 7 and 14 respectivelyResults Out of 84 patients 30 were males and 54 were females with male to female ratio of 118 The House wives were affected more among all female patients 51 In group A and B 42 cases were included in the study and they completed the follow up till 14th day In group A after second week of follow up 25 cases noted good response 10 cases explained it as very good and in 6 cases satisfying response was seen which was statistically significant plt005 In group B also 42 cases which completed the study after second week 22 cases achieved satisfaction 17 cases good and 3 cases very good responseConclusion Oral Nifedipine 10 mg three times a day was more effective in lower doses among Indian patients with least possible side effects as compared to Topical 5 Minoxidil Gel therapy in the management of perniosisKeywords Perniosis Nifedipine Minoxidil North western India
Authors and Affiliations
Akshay Kumar Jain, Raghavendra K. R, Mansaree Margaankar
Keywords
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- EP ID EP488953
- DOI 10.18231/.2018.0014
- Views 89
- Downloads 0
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