A Randomised control study on effects of autologous platelet rich plasma injection in early osteoarthritis knee by single dose versus double dose regimen
Journal Title: Indian Journal of Orthopaedics Surgery - Year 2018, Vol 4, Issue 2
Abstract
Materials and Methods A total of 263 knees 150 patients males 65 females 85 with early OA were divided randomly into two groups Group A 75 patients 134 knees received a single injection of PRP group B 75 patients 129 knees received 2 injections of PRP 3 weeks apart PRP with a platelet count 5 times that of baseline was administered in all Clinical outcome was evaluated using the Western Ontario and McMaster Universities Arthritis Index WOMAC questionnaire before treatment and at 1 month 3 month and 6 months post injection A reduction in WOMAC score is suggestive of improvement in patient conditionResults significant improvement in all WOMAC parameters was noted in groups A and B within 3 to 4 weeks and lasting until the final followup at 6 months The mean WOMAC scores pain stiffness physical function and total score for group A at baseline were 158 622 4309 and 6511 respectively and at final followup were 483 100 1412 and 1995 respectively showing significant improvement Similar improvement was noted in group B mean WOMAC scores at baseline 1651 691 4198 and 6538 respectively mean WOMAC scores at final follow up 550 112 1369 and 2037 respectively The 2 groups were compared with each other and no improvement was noted in group B as compared with groups A P value 077Conclusion Autologous PRP infiltration in early Osteoarthritis of Ahlbacks radiological grading does give relief from pain stiffness and improves functionality without any major side effects Double dose doesnt offer any additional advantageKeywords Platelet rich plasma Early osteoarthritis knee
Authors and Affiliations
K. Deepak, Hameed Reza, G. Jagadesh, Akash, Pavan Kumar
Keywords
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- EP ID EP476607
- DOI 10.18231/2395-1362.2018.0036
- Views 91
- Downloads 0
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