A randomized clinical study comparing the analgesic efficacy of intra venous patient- controlled analgesia of morphine with fentanyl in post-operative pain management of major surgery patients
Journal Title: National Journal of Physiology, Pharmacy and Pharmacology - Year 2017, Vol 7, Issue 12
Abstract
Background: Post-operative pain is a protective but an unwanted effect which is to be treated for the better outcome of surgery. Aims and Objectives: The aim of this study is to compare the safety and analgesic efficacy of intravenous patient-controlled analgesia (IV PCA) using morphine and fentanyl for post-operative pain management in major surgery patients. Materials and Methods: The randomized clinical study initiated after the ethics committee approval and informed consenting. A total of 60 patients belonging to the American Society of Anesthesiology Grade - I, II, and III physical status, scheduled for major abdominal, oncological surgeries under general anesthesia were randomly allocated to two groups. Group M received IV PCA with morphine (basal continuous infusion 0.02 mg/kg/h, bolus dose of 0.02 mg/kg, and lockout period of 20 min), and the Group F received IV PCA with fentanyl (basal continuous infusion 0.5 µg/kg/h, bolus dose of 0.5 µg/kg, and lockout period of 20 min). Fentanyl dosage was converted into morphine equivalents. The outcomes such as visual analog scale (VAS), sedation score, hemodynamic parameters, and adverse effects were compared between groups and analyzed statistically. Results: Morphine provides better analgesia than fentanyl as indicated by lower VAS scores (score = 3) at the end of 24-72 h. Mean cumulative analgesic consumption was higher in fentanyl group (436.3 ± 330.2 mg) compared with morphine group (123.9 ± 28.2 mg) by 72 h. Regarding the hourly consumption, Group M consumed less drug than fentanyl group was statistically significant (P = 0.05). Conclusion: Morphine provides more effective post-operative analgesia than fentanyl administered through IV PCA. The PCA allows patients to balance between administration of analgesics and adverse events by self-adjusting the dose of analgesic used.
Authors and Affiliations
Brijesh Kumar, Suresha K Ramakrishnappa, Maina Bekal
Keywords
Related Articles
- EP ID EP292767
- DOI 10.5455/njppp.2018.8.1039208102017
- Views 85
- Downloads 0
Sleep duration and its association with obesity and overweight in medical students: A cross-sectional study
Background: The prevalence of sleep deprivation is rising globally as is that of obesity. The association between the two is also gaining much evidence. The medical students may be specifically affected due to decreased...
Role of yoga in attention, concentration, and memory of medical students
Background: The processes of attention, concentration, and memory are the main factor in learning. Yoga is an ancient technique which is claimed to enhance physical and mental well-being. Aims and Objectives: The aim of...
Determination of hematological values and detection of Chlamydophila psittaci antibodies in captive blue-naped parrots at the Ninoy Aquino Parks and Wildlife Nature Center
Background: Tanygnathus lucionensis lucionensis, also known as the blue-naped parrot, is endemic to Luzon and Mindanao and is known for their distinctive blue crown and nape. Aims and Objectives: Being indigenous to the...
Comparison of the effect of two selected resistance training patterns on some physical and physiological factors of elite freestyle wrestler young boys
Background: Wrestling is a sport heavy and severe activity due to certain physical and physiological needs such as anaerobic, power, strength, speed, lactate tolerance, and anaerobic stamina because wrestling matches are...
A glimpse into the pathophysiology, mechanisms, and management of neuropathic pain
One of the most frequent problems in medical care is the management of patient presenting with chronic pain. Neuropathic pain is related to the injury or disorders affecting peripheral and central nervous systems...