A RANDOMIZED CLINICAL TRIAL ON THE ANTI-INFLAMATORY EFFECT OF INTRACAMERAL LOW MOLECULAR WE HEPARIN (ENOXAPAIN) IN DIABETIC CATARACT SURGERY
Journal Title: Journal of Evidence Based Medicine and Healthcare - Year 2015, Vol 2, Issue 35
Abstract
To study the effect intracameral low molecular weight on postoperative inflammation after cataract surgery in diabetic patients. SETTING: Department of Ophthalmology J. N. Medical College. Belgaum. DESIGN: Randomized control trial. MATERIAL AND METHODS: Forty patients with diabetes undergoing small incision cataract surgery with posterior chamber intraocular lens (IOL) implantation were randomly assigned to two groups, group A and group B. All patients in group A received low molecular weight heparin (enoxaparin) in the concentration of 40 IU in 500ml in the irrigating solution and patients in group B received irrigating solution without low molecular weight heparin. In all patients polymethyl methacrylate (PMMA) IOLs were implanted. The patients were examined postoperatively on day 1, day 7, day 30 and day 60 for anterior chamber cells and flare and iris pigments on cell by slit lamp biomicroscopy. RESULTS: A statistically significant reduction in postoperative cells, flare and intraocular lens surface pigments was noted in group with addition of low molecular weight heparin (enoxaparin) at day 1(p0.001) and 1 week (p<0.001). At 4 weeks and 8 weeks no statistically significant reduction in post-operative cells and flare was seen between the two groups but there was a significant reduction in the intraocular lens pigments in the group with addition of low molecular weight heparin (enoxaparin). CONCLUSION: Intraoperative use of low molecular weight heparin (enoxaparin) reduced disturbance in the blood-aqueous barrier in the early post-operative period evidenced by lower postoperative anterior chamber cells and flare, and also reduced iris pigments on the intraocular lens. At 8 weeks cells and flare in both the groups did not show significant difference.
Authors and Affiliations
Shivanand Bubanale, Umesh Harakuni, Bhagyajyothi B. K. , Smitha K. S. , Kshama K. , Arvind Tenagi, Sneha Harogappa, Shreya Raiker
Keywords
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- EP ID EP231920
- DOI 10.18410/jebmh/2015/758
- Views 71
- Downloads 0
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