A Randomized Clinical Trial Study of the Effects of Varicocelectomy on Sperm Clinical Analysis and DNA Fragmentation: A Preliminary Data
Journal Title: Gynecology and Obstetrics Research – Open Journal - Year 2015, Vol 2, Issue 1
Abstract
Varicocele is a disease characterized by abnormal dilatation of the testicular veins within the pampiniform plexus due to difficult blood return in this region. The prevalence of varicocele is 30 to 40% in infertile men, who frequently show seminal changes and a high rate of sperm DNA Fragmentation Index (DFI), one of the conditions responsible for failure of spermatogenesis. Several studies have demonstrated that varicocelectomy may improve the seminal parameters and even the quality of genetic material. However, published papers are predominantly retrospective rather than prospective. In this study, we show some effects of varicocelectomy on the seminal quality and DFI rate of men who were submitted compared to men who did not undergo the procedure, before and after nine months of the intervention. This preliminary data was a prospective, randomized and controlled clinical trial in which 15 men with varicocele and five men without varicocele (control group) were included. In the varicocele group, five patients were submitted to varicocelectomy and 10 were not. The DFI rate was analyzed using the Halosperm G2® kit and the seminal parameters were assessed according to the criteria established by the World Health Organization (WHO), 2010. A difference in DFI rate was detected between the varicocele (52% ± 0.28) and the control group (27% ± 0.07). In the varicocele group, no differences in DFI rate were observed between patients submitted to varicocelectomy and patients who were not submitted to the procedure, however, we could observe a sharp increase in the sperm concentration of patients who underwent surgery (28.33 x 106 /ml ± 26.91) compared with not submitted varicocelectomy (3.03 x 106 /ml ± 14.74). These preliminary results emphasize that men with varicocele have a higher DFI rate.
Authors and Affiliations
Rosana Maria dos Reis
Keywords
Related Articles
- EP ID EP553490
- DOI 10.17140/ GOROJ-2-107
- Views 201
- Downloads 0
Outcome of Stepwise Uterine Sparing Approach as a Conservative Surgical Management of Placenta Accreta
Introduction: The incidence of placenta accreta is rising as a consequence of increased rate of cesarean sections and placenta previa which is the strongest risk factor. Intractable postpartum hemorrhage associated with...
Placental Retention with Accreta in a Uterine Anomaly
A 32 year-old P1 G2 went into spontaneous labour at 37 weeks gestation. Precipitate labour progressed to a normal vaginal delivery (NVD) of a baby boy within 2 hours of onset. She had a retained placenta. The patient was...
Pregnancy in Takayasu Arteritis Patients Exposed to Anti-Tumour Necrosis Factor (Anti-TNF)-α Therapy
Anti-TNF agents, IFX in particular,1 appear safe and effective in rheumatic patients during pregnancy. Here, we described two successful pregnancies of TA patients treated with IFX before conception and until 28 wg. Bloo...
Abdominal and Pelvic Adhesions Research in Sub-Saharan Africa: Air Must Become Wind
Abdominal and Pelvic Adhesions (APA) are pathological fibrotic bands developed between any surfaces in the abdominal and pelvic cavities.1 They can be congenital or derive from surgery, infections, inflammation, malignan...
Pregnancy and Childbirth in Patients With Syndrome-MarfanPregnancy and Childbirth in Patients With Syndrome-Marfan
Marfan syndrome (MFS) is an autosomal dominant condition with a reported incidence rate of 1 in 3000 to 5000 individuals. The majority of cases of MFS are caused by a mutation in the fibrillin-1 gene (FBN1). Transforming...