A Randomized Control Trial Comparing Propofol with Midazolam and Fentanyl Combination for Sedation in Gastrointestinal Endoscopies
Journal Title: International Journal of Contemporary Medical Research - Year 2016, Vol 3, Issue 8
Abstract
Introduction: Propofol can be easily titrated and has a rapid recovery profile, thus has revolutionised sedation practices in gastrointestinal (GI) endoscopy. The objective of this study was to compare efficacy and safety of propofol with midazolam and fentanyl combination for GI endoscopy sedation. Material and methods: Sixty patients scheduled for gastrointestinal endoscopy were recruited for this study. Patients were randomly allocated into either Group P (propofol alone) or Group MF (combination of midazolam and fentanyl). The parameters used to measure the efficacy were, time of onset of sedation, depth of sedation (Ramsays sedation scale), amnesia and early recovery of sedation (Modified Aldrete Score). Safety was evaluated using cardiovascular and respiratory parameters. Adverse events like hypoxia, hypotension, bradycardia were recorded. PSPP software was used for statistical analysis. Results: It was observed that P group patients were more deeply sedated with a mean RSS of 5.1 compared to 3.07 of the MF group. Full recovery (Aldrete score 10) at ten minutes after the end of the procedure was seen in 73.33% of the patients of the propofol group compared to 50% of the MF group which was insignificant. Propofol group had significant haemodynamic changes (hypotension ) as compared to MF group. Respiratory complications were seen in both the groups but they were few and not significant. Conclusion: We conclude that both the groups are of same merit and safe. Keywords:
Authors and Affiliations
Urvi H. Desai, Deepa Shriyan, Dipankar Dasgupta
Keywords
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