A randomized, controlled clinical trial comparing efficacy, safety and cost effectiveness of Lornoxicam with Diclofenac Sodium in patients of osteoarthritis knee
Journal Title: Internet Journal of Medical Update - Year 2011, Vol 6, Issue 2
Abstract
Osteoarthritis is a chronic painful condition affecting larger joints; most commonly knee joint. Pharmacological control of pain is the mainstay of management of osteoarthritis. Many patientsfail to achieve satisfactory reduction in pain with one of the most commonly prescribed drugs, diclofenac sodium, even after maximum daily allowed doses. Lornoxicam is a newer molecule in the Indian market promising better pain relief in context of low back pain and post knee replacement surgery pain as compared to standard therapies. As per profile of lornoxicam, if it is better than diclofenac sodium then it will be helpful in managing the patients of osteoarthritis more effectively. Till date no comparative clinical trial has been done to compare these two drugs for the management of osteoarthritis knee. So, to evaluate the same we carried out this study to compare safety, efficacy and cost effectiveness of lornoxicam and diclofenac sodium in relieving pain in patients of osteoarthritis knee. This study is a randomized, open labeled, controlled clinical trial having 40 newly diagnosed patients with osteoarthritis knee. After random allocation into two groups i.e. group D and group L (each having 20 patients); group D received diclofenac sodium 50 mg 12 hourly and group L received lornoxicam 4 mg 8 hourly for a period of 3 months. All patients were assessed with visual analogue scale and 100 meter walking test before starting of therapy, at 15 days and at 1, 2 and 3 months of therapy. Adverse drug reactions and cost of therapy was monitored during the study period. Mean decrease in visual analogue scale and time of 100 meter walking test was statistically significant in lornoxicam group as compared to diclofenac sodium. Gastric irritation was reported in one patient from group L and two patients from group D. Lornoxicam significantly relieves pain of osteoarthritis knee than diclofenac sodium without adversely affecting the tolerability to the patients.
Authors and Affiliations
Vishalkumar Vadgama, Ripal Gharia, Kalpesh Mehta, Ravisaheb Sanjiv, C Tripathi
Keywords
Related Articles
- EP ID EP102871
- DOI -
- Views 126
- Downloads 0
NANOPARTICLES IN NUCLEAR IMAGING
The present review article summarizes the current state radiolabeled nanoparticles for molecular imaging applications mainly targeting cancer. Due to their enormous flexibility, and versatility the radiolabeled nanoparti...
Clinical implications of ST segment time-course recovery patterns during the exercise stress test
The exercise stress test (EST) is the commonest non-invasive test to elucidate the nature of chest pain/discomfort. ST segment depression provides evidence of ischemia, but is hampered by a significant number of false ne...
RADIATION EXPOSURE FROM DIAGNOSTIC RADIOGRAPHY: AN ASSESSMENT OF X-RAY BEAM COLLIMATION PRACTICE IN SOME NIGERIAN HOSPITALS
This study was carried out to evaluate the X-ray beam collimation practice, among radiographers, as a measure of radiation protection for patients undergoing radiodiagnostic investigations. Inadequate X-ray beam collimat...
Vincristine: a new treatment option for Kasabach-Merritt Syndrome
Kasabach-Merritt syndrome (KMS) is characterized by a rapidly enlarging hemangioma, thrombocytopenia, microangiopathic hemolytic anemia and consumption coagulopathy as a result of platelet and red blood cell trapping and...
Evaluation of left ventricular structures in normotensive and hypertensive subjects by two-dimensional echocardiography: Anthropometric correlates in hypertension
This study was conducted with the objective to establish a nomogram for some left ventricular structures and their alterations in hypertension. Correlations between left ventricular structures and anthropometric variable...