A Randomized Controlled Study on Effect of Dexmeditomidine for Stress Response Attenuation due to Laryngoscopy and Intubation
Journal Title: International Journal of Medical Research Professionals - Year 2017, Vol 3, Issue 3
Abstract
Aims: This study was designed to study the efficacy of intravenous dexmedetomidine for attenuation of cardiovascular responses to laryngoscopy and endotracheal intubation in patients in different age group, either sex belonging to ASA I and ASA II scheduled for elective surgical procedures under general anaesthesia. Methods: Sixty adult patients scheduled for elective surgical procedures were randomly allocated to receive dexmedetomidine (0.5 mcg/kg) or normal saline over 20 min before intubation. Patients were compared for hemodynamic changes (HR, SBP, DBP, and MAP) at baseline, 1, 3, 5 & 10 min after intubation. Results: Basal mean heart rate between group I and group II was not significant (p = .575) and as pre-induction, induction 1, 3, 5 & 10 minutes after intubation the HR changes were significant. In group II there was constant decrease in HR from the time of preinduction until 10 minutes of intubation which was statistically highly significant as compared to group I. Basal mean SBP between group I and group II was not significant (p= .123), at preinduction was also not significant (P=.104), at induction, 1, 3, 5 & 10 minutes after intubation the SBP changes were highly significant (p= .000). In group II, SBP continued to remain below the base value from the time of pre-induction until 10 minutes after intubation which was statistically significant. Basal mean DBP between group I and group II was not significant (p= .956), at preinduction was significant (P= .003), at induction, 1, 3, 5 & 10 minutes after intubation the DBP changes were highly significant (p= .000). In group II, there was constant decrease in DBP from the time of induction until 10 minutes after intubation which was statistically significant. Basal mean MAP between group I and group II was not significant (p= .956), at preinduction was significant (p= .003), at induction, 1, 3, 5 & 10 min after intubation the DBP changes were highly significant (p=.000). In group II, there was a constant in MBP from the time of pre-induction until 10 minutes of intubation which was statistically significant. Conclusion: From the present study it is obvious that dexmedetomidine produces stable heart rate, provides greater cardiovascular stability, attenuates pressure response as well as tachycardia and prevents postoperative shivering, nausea and vomiting.
Authors and Affiliations
Ratan Kumar Choudhary, Atul Kaushik, Shailza Sharma, S K S Puri
Keywords
Related Articles
- EP ID EP548060
- DOI 10.21276/ijmrp.2017.3.3.044
- Views 93
- Downloads 0
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