A RANDOMIZED CONTROLLED TRIAL TO EVALUATE THE ANTI-INFLAMMATORY EFFECT OF COMMIPHORA WIGHTII IN COMBINATION WITH CURCUMA LONGA AGAINST DICLOFENAC POTASSIUM IN NON-SPECIFIC KNEE EFFUSION
Journal Title: Journal of Biological and Scientific Opinion - Year 2015, Vol 3, Issue 2
Abstract
Knee effusion is an abnormal accumulation of the fluid in the knee capsule or the adjoining supra-patellar bursa secondary to the irritation/inflammation in the joint synovium. It is seen in approximately 8-10 % of the total patients suffering from osteo-arthrosis. Kroṣṭukaśīrṣaas described in Ayurveda, can be corelated with knee effusion. In Present clinical trial an effort has been made to evaluate anti-inflammatory effect of Commiphora wightii in combination with Curcuma longa against Diclofenac potassium [NSAID’s] in Non-specific knee effusion. Total twenty two, clinically diagnosed patients of Non-specific knee effusion were selected for the present clinical trial excluding drop out 20 patients were assorted in to two groups Trial Group and control Groups. Trial Group 10 patients were given crude extract of Commiphora wightii 500 mg along with Curcuma longa 500 mg in a separate capsule twice a day continuously for 8 weeks orally. In Control Groupten patients were given Diclofenac Potassium 50 mg twice a day continuously for 2 weeks orally. It was assessed that Diclofenac potassium was significantly better in the outcomes in comparison to the trial drugs Commiphora wightii (Guggulu) and Curcuma longa (Haridra) when compared at the end of two weeks of start of the trial. Trial drugs Commiphora wightii (Guggulu) and Curcuma longa (Haridra) are also having outcomes of comparative extent to Diclofenac Potassium when administered continuously for further 6 weeks i.e. total 8 weeks.
Authors and Affiliations
Narinder Singh, A. R. Bhattacharya, Akhilesh Mishra
Keywords
Related Articles
- EP ID EP127415
- DOI 10.7897/2321-6328.03215
- Views 94
- Downloads 0
ANALYTICAL EVALUATION OF ROLE OF SARSHAPATAILA MURCHANA IN THE PREPARATION OF GANDHAKATAIALA
‘Aadousammurchayet sneham’ the famous quotation has been explained in the classical text Bhaishajya Ratnavali. Prior to the preparation of any type of medicated oils, murchana a kind of pharmaceutical processing on crude...
PHYSICO CHEMICAL EVALUATION AND CHARACTERIZATION OF DIFFERENT TYPES OF CAMPHOR USED IN AYURVEDIC FORMULATIONS
Classical Ayurvedic Texts refer to the use of Kapur in many Ayurvedic Medicines. Ayurvedic Pharmacopoeia of India records Natural Camphor obtained during steam distillation of the leaves and barks of Cinnamomum camphora...
ANTIOXIDANT AND FREE RADICAL SCAVENGING ACTIVITY OF ESSENTIAL OIL EXTRACTED FROM ROSMARINUS OFFICINALIS L.
Free radicals/reactive oxygen species are related to many biological phenomena such as inflammation, aging, and carcinogenesis. In this work, we studied antioxidant activity oils extract of leaves Rosmarinus officinalis....
IN VITRO STUDIES ON CALLUS INDUCTION OF ECLIPTA ALBA (L.) HASSK: AN IMPORTANT PLANT OF TRADITIONAL MEDICINE
An efficient method was developed for rapid and large-scale in vitro clonal propagation of the valuable medicinal herb Eclipta alba (Asteraceae). Different explants were tried, and best results were obtained by axillary...
GINGIVAL ENLARGEMENT: AN ISSUE OF PINK TISSUE: CASE SERIES
Increase in size of gingiva is a common feature of gingival disease. Accepted current terminology for this condition is gingival enlargement and gingival overgrowth. Gingival enlargement may result from chronic or acute...