A Randomized Double-blind Control Study Comparing the Efficacy of Palonosetron Versus a Combination of Dexamethasone with Palonosetron in Preventing Post-operative Nausea and Vomiting in Patients Undergoing Laparoscopic Cholecystectomy
Journal Title: INTERNATIONAL JOURNAL OF SCIENTIFIC STUDY - Year 2018, Vol 6, Issue 6
Abstract
Introduction: Post-operative nausea and vomiting (PONV) is distressing symptoms occurring after anesthesia and surgery with incidence of about 20–30% during the first 24 post-operative hours. In patient undergoing laparoscopic cholecystectomy (LC), the incidence is as high as 63–72%. Objective: The objective of this study was to compare the efficacy of “palonosetron” versus a combination of “dexamethasone and palonosetron” in preventing PONV in patients undergoing LC. Materials and Methods: A total of 84 patients were randomized into two groups. Group I received palonosetron (0.075 mg) and Group II received a combination of palonosetron (0.075 mg) and dexamethasone (8 mg). Incidence of PONV was measured using visual analog score from the time of arrival to recovery until discharge at specified intervals. The absence of nausea and vomiting was considered as complete response (CR). Requirement of rescue antiemetic (metoclopramide) in each group was noted. Results: At 0–2 h, CR of 85.7% in Group II and 66.7% in Group I was observed (P = 0.040). During 2–24 h, CR in Group II in comparison to Group I (88.1% vs. 69%, P = 0.033) was more. During 0–24 h, CR of 85.7% of patients in Group II and 66.7% of patients in Group I (P = 0.040) was observed. Between 24 h till discharge, 100% in Group II and 97.6% in Group I showed CR (P = 0.314). Requirement for rescue antiemetic was higher in Group I (P = 0.026). Conclusion: A combination of palonosetron and dexamethasone significantly reduced the incidence of PONV during the first 24 h. After 24 h, both groups showed similar efficacy.
Authors and Affiliations
S Dinesh Kumar, A Madhu Yadav, K Bhaskaran
Keywords
Related Articles
- EP ID EP481626
- DOI -
- Views 79
- Downloads 0
A Study on Surgical Management of Carcinoma Stomach
Introduction: Cancer is known as one of the major causes leading to many disorders, death, and disabilities worldwide. Among all organ cancers, gastrointestinal tract cancers present an interesting pattern in distributio...
Acinetobacter spp. an Emerging Pathogen of Septicemia in a Tertiary Care Hospital
Introduction: Bloodstream infections are an important cause of patients serious morbidity and mortality worldwide. Changing bacterial flora and emergence of resistant strains further aggravate the problem. Acinetobacter...
A Study on Prescribing Trends of Drugs in the Management of Bronchial Asthma: A Hospital-Based Study
Background: Bronchial asthma is a common allergic condition with varied symptoms and necessitates the attention of the physician especially in acute attacks and poses a challenge to treat. Treatment to overcome the acute...
A Comprehensive Study on Post Traumatic Temporal Contusion in Adults
Introduction: The brain undergoes various types of strain during injury. The strain may be in the form of compression, tensile strain or shear strain. More than one type of mechanics and more than one type of strain are...
Smartphone Use among Healthcare Providers in Saudi Arabia: A Cross-sectional Study
Introduction: Distraction due to smartphone use in healthcare settings is a threat to patient safety. There are growing concerns regarding its negative impacts on health providers’ performance and image. Purpose: The aim...