A Rare Case of Primary Plasma Cell Leukaemia with Monosomy X
Journal Title: Journal of Clinical and Diagnostic Research - Year 2017, Vol 11, Issue 8
Abstract
Primary Plasma Cell Leukaemia (pPCL) is a very rare and aggressive subtype of plasma cell dyscrasias with a very poor outcome and characterized by presence of >2x109 /l circulating plasma cells. Overall incidence being 1%-2% of all malignant plasma cell diseases and 0.9% of all acute leukaemias. Patients with primary and secondary PCL have similar clinical features but differences do exist. Here we report a rare and interesting case diagnosed as primary PCL in a 44-year-old female with unusual clinical presentation and complex karyotyping. Her serum electrophoresis showed a monoclonal IgG component and immunohistochemistry of bone marrow plasma cells showed CD 38 positive and CD 20 negative. The patient initially responded partially for combination chemotherapy, but succumbed after 20 days of diagnosis. We are presenting this case to highlight the importance of early diagnosis of such haematological malignancies in settings where treatment options like stem cell transplantation are limited.
Authors and Affiliations
smita surendra masamatti, aparna narasimha, archana c shetty, C vijaya
Keywords
Related Articles
- EP ID EP358256
- DOI 10.7860/JCDR/2017/28512.10367
- Views 76
- Downloads 0
Giant Cell Reparative Granuloma of Proximal phalanx of 4th Toe-A Rare Case Report
ABSTRACT Giant Cell Reparative Granuloma (GCRG) is locally aggressive, non-neoplastic lesion. It is an uncommon lesion commonly found in maxilla and mandible and rare in the toes. Due to absence of classical radiological...
A Prospective Analysis of Drug Interactions in Patients of Intensive Cardiac Care Unit
Introduction: Drug-Drug Interaction (DDI) is a serious concern in cardiac patients due to polypharmacy. Aim: The present study was aimed to identify the potential DDI among hospitalized cardiac patients and evaluate the...
A Rare Case of Giant Solitary Neurofibroma of Abdominal Wall Masked by Pregnancy
Various types of neurogenic tumours can involve the abdomen. Retroperitonial space is most commonly affected but other sites can also be involved. Mostly younger age group is affected and malignant transformation is rare...
Biomechanical Study of Trapezoidal Plate, Delta Plate and Miniplate in Subcondylar Fracture
ABSTRACT Introduction: Condylar fracture accounts for 25-35% of all mandibular fracture. When it comes to open reduction and internal fixation, the design of the plate plays a crucial role to withstand the amount of mas...
Sonographic Estimation of Umbilical Cord Cross-section Area and its Reference Value in Normal Pregnancy
Introduction: The routine antenatal sonographic investigations of the umbilical cord are limited for assessment of number of umbilical vessels and doppler evaluation of umbilical blood flow. With the advancements of the...